Browsing by Author "El-Osaily, Ghada H."

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    Characterization and Pharmacological Evaluation of Anti-Cellulite Herbal Product(s) Encapsulated in 3D-Fabricated Polymeric Microneedles
    (nature, 2020-12) I.Amer, Reham ; El-Osaily, Ghada H.; Bakr, Riham Omar; El Dine, Riham Salah; Fayez, Ahmed
    Skin health is vital for a healthy body. Herbal remedies have long been used for skin care, and their global use has tremendously increased over the past three decades. Although cellulite is seen as a normal condition by the medical community, it is considered a serious cosmetic concern for most afected women. Many topical anti-cellulite creams are available on the market, but unfortunately, their efcacy has not been proven scientifcally. Microneedles (MNs) represent a new approach to enhance the permeation of loaded medication through the skin. In this study, the anti-cellulite efects of Vitex agnus-castus and Tamarindus indica extracts were compared using safe and efective polymeric MNs. This delivery system ofers a painless alternative to the combined treatment strategy of microneedling devices and anti-cellulite products. The selected standardized extracts were evaluated for their mineral, phenolic and favonoid contents, which are correlated to a promising antioxidant efect, as demonstrated by an in vitro radical scavenging activity assay. 3D-printing techniques were chosen for fabrication of a micromold, which is inexpensive for mass production. To ensure that MNs were sufciently strong to perforate the skin without breaking, axial failure force was measured using a micro-mechanical test machine. The anticellulite efects of MNs were assessed using an in vivo diet- induced obesity guinea pig model. Skin properties, histopathology and infammatory markers were examined. MNs loaded with plant extracts were statistically comparable in normalizing the oxidative state and reducing infammation, while myeloperoxidase levels were more signifcantly reduced by T. indica than by V. agnus-castus. This novel delivery system opens the door for new transdermal strategies for cellulite management