Browsing by Author "El-Arab E.E."

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    The reaction of cyanoacetic acid hydrazide with 2-acetylfuran: Synthesis of coumarin, pyridine, thiophene and thiazole derivatives with potential antimicrobial activities
    (2009) Mohareb R.M.; El-Arab E.E.; El-Sharkawy K.A.; Faculty of Pharmacy; October University for Modern Sciences and Arts; Elwahaat Road; October City; Egypt; Faulty of Science; Chemistry Department; Cairo University; Egypt; National Organization of Drug Control and Research (NODCAR); P.O. 29; Cairo; Egypt
    The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2-10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs. � Mohareb et al.; licensee �sterreichische Apotheker-Verlagsgesellschaft m. b. H.