Browsing by Author "Bakr, Riham Omar"
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Item Characterization and Pharmacological Evaluation of Anti-Cellulite Herbal Product(s) Encapsulated in 3D-Fabricated Polymeric Microneedles(nature, 2020-12) I.Amer, Reham ; El-Osaily, Ghada H.; Bakr, Riham Omar; El Dine, Riham Salah; Fayez, AhmedSkin health is vital for a healthy body. Herbal remedies have long been used for skin care, and their global use has tremendously increased over the past three decades. Although cellulite is seen as a normal condition by the medical community, it is considered a serious cosmetic concern for most afected women. Many topical anti-cellulite creams are available on the market, but unfortunately, their efcacy has not been proven scientifcally. Microneedles (MNs) represent a new approach to enhance the permeation of loaded medication through the skin. In this study, the anti-cellulite efects of Vitex agnus-castus and Tamarindus indica extracts were compared using safe and efective polymeric MNs. This delivery system ofers a painless alternative to the combined treatment strategy of microneedling devices and anti-cellulite products. The selected standardized extracts were evaluated for their mineral, phenolic and favonoid contents, which are correlated to a promising antioxidant efect, as demonstrated by an in vitro radical scavenging activity assay. 3D-printing techniques were chosen for fabrication of a micromold, which is inexpensive for mass production. To ensure that MNs were sufciently strong to perforate the skin without breaking, axial failure force was measured using a micro-mechanical test machine. The anticellulite efects of MNs were assessed using an in vivo diet- induced obesity guinea pig model. Skin properties, histopathology and infammatory markers were examined. MNs loaded with plant extracts were statistically comparable in normalizing the oxidative state and reducing infammation, while myeloperoxidase levels were more signifcantly reduced by T. indica than by V. agnus-castus. This novel delivery system opens the door for new transdermal strategies for cellulite managementItem Formulation, Characterization and Antimicrobial efficacy of Aegle marmelos Essential oil nanogel(Research Journal of Pharmacy and Technology, 2021-07) Bakr, Riham Omar; Zaghloul, Soumaya Saad; Amer, Reham Ibrahim; Mostafa, Dalia Abd Elaty; El Bishbishy, Mahitab HelmyObjective: Aegle marmelos (L.) Correa has been widely used in Indian traditional medicine and has many reported pharmacological activities. The aim of this research was to formulate solid lipid nanoparticles (SLNs) of Aegle oil (AO) that enhanced the beneficial antimicrobial activity of the oil. Methods: The chemical composition of Aegle leaf essential oil was analysed by GC-MS. Additionally, a phytochemical study of A. marmelos methanolic leaf extract was conducted using Folin-Ciocalteu colorimetric assay for determination of total phenolic content as well as ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-ESI-MS-MS) analyses for identification of individual components. Six formulations of AO-loaded SLNs (AO-SLNs) were prepared by a double emulsification method. The particle size, zeta potential (ZP), polydispersibility index (PDI) and drug encapsulation efficiency (EE) of the SLNs were determined. The morphology of the SLNs was observed by transmission electron microscopy (TEM). The antimicrobial activity of AO and AO-SLNs was assessed using disc diffusion method. Results: Thirty-two compounds were identified in the Aegle oil, of which Δ-carene and α-phellandrene were the most abundant (48.14% and 34.14%, respectively). The estimated total phenolic content was 968mg gallic acid equivalents (GAE)/g, while UPLC-ESI-MS-MS led to the tentative characterization of thirteen metabolites. The SLNs showed ZP, PDI and EE 125 ± 0.22nm, –37.85, 0.282, and 92%, respectively. AO and AO-SLNs showed significant antimicrobial activity, and the SLNs could sustain the release of AO from their gel vehicles. Conclusion: Our results provide evidence for the application of AO-SLNs in topical and transdermal delivery systems. © RJPT All right reserved.