Browsing by Author "Ayoub N."

Filter results by typing the first few letters
Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Acylated flavonol diglucosides from Ammania auriculata
    (Verlag der Zeitschrift fur Naturforschung, 2015) Nawwar M.; Ayoub N.; El-Raey M.; Zaghloul S.; Hashem A.; Mostafa E.; Eldahshan O.; Lindequist U.; Linscheid M.W.; National Research Center; Department of Phytochemistry and Plant Systematics; El Bohooth Str.; P.O. 12622; Dokki; Cairo; Egypt; Faculty of Pharmacy; Department of Pharmacognosy; Ain-Shams University; Cairo; Egypt; October University for Modern Sciences and Arts; 6th October City; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; Institute of Pharmacy; Pharmaceutical Biology; Ernst-Moritz-Arndt-Universit�t Greifswald; Greifswald; Germany; Laboratory of Applied Analytical and Environmental Chemistry; Department of Chemistry; Humboldt-Universit�t zu Berlin; Berlin; Germany
    Chemical investigation of the extract of the whole Ammania auriculata plant resulted in the identification of 13 polyphenols, including the hitherto unknown flavonoids, kaempferol 3-O-?-(6?-galloylglucopyranoside)- 7-O-?-glucopyranoside, and its quercetin analogue. The structures of all isolates were elucidated by conventional methods, spectroscopic analysis, including 1D and 2D NMR, and by HRESI-MS as well.
  • Thumbnail Image
    Item
    Botanical and genetic characteristics of Lobularia libyca (viv). C.F.W. Meissn. (Brassicaceae)
    (International Journal of Pharmacognosy and Phytochemical Research, 2014) Zaghloul S.S.; Nematallah K.A.; Al-Gendy A.A.; Ayoub N.; Pharmacognosy Department; October University for Modern Sciences and Arts (MSA); Giza; Egypt; Pharmacognosy Department; Zagazig University; Al-Sharkiya; Egypt; Pharmacognosy Department; Ain-Shams University; Cairo; Egypt; Pharmacognosy Department; BUE University; Cairo; Egypt
    Lobularia libyca (viv). C.F.W. Meissn. is an annual herbaceous desert plant native to North Africa belonging to Family Brassicaceae (Cruciferae). Study of the botanical features was carried out for the root, the young and old stems, leaf, flower and seed of the plant. L. libyca was characterized by the presence of non-glandular branched unicellular two armed hair in the stem, leaf and flower while the root shows narrow cork and xylem occupies about 80% of the diameter of the root. The flower is characterized by hairy sepals and spherical pollen grains with three germ pores and three germ furrows. The pericarp is characterized by hairy epicarp and presence of fibrosclerides as innermost layer of the mesocarp. The septum shows pitted lignified parenchyma. The seed shows accumbent embryo and the testa is characterized by the presence of pigment layer with reddish brown content. The DNA of the plant was extracted from leaf samples and analyzed using eleven random decamer primers. A total of 89 random amplified polymorphic DNA (RAPD) markers were identified. Both the botanical study and the DNA fingerprint helped in the identification of the plant.
  • Thumbnail Image
    Item
    Phenolic profile of centaurea aegyptiaca L. Growing in Egypt and its cytotoxic and antiviral activities
    (African Ethnomedicines Network, 2016) Bakr R.O.; Mohamed S.A.E.H.; Ayoub N.; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); Egypt; Department of Pharmacognosy; Faculty of Pharmacy; Al-Azhar University (Girls); Egypt; Department of Pharmacognosy; Faculty of Pharmacy; British University in Egypt (BUE); Egypt
    Background: Centaurea aegyptiaca L (Asteraceae), is one of the most attractive plants growing wildly in Sinai, and is not well investigated for its phytochemical constituents. This study represents the first in-depth characterization of the phenolic profile of the aerial parts of C. aegyptiaca methanolic extract utilizing liquid chromatography (LC) combined with electrospray ionization (ESI) tandem mass spectrometry (MS/MS). Material and Methods: Phenolic profile was researched utilizing LC-HRESI-MS-MS. Assessment of cytotoxic activity against four human cancer cell lines (Hep-G2; hepatocellular carcinoma cells, MCF-7; breast adenocarcinoma cells, and HCT-116; colon carcinoma and HELA; cervical carcinoma cells) was performed using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Antiviral activity was surveyed utilizing cytopathic effect inhibition assay. Results: A total of sixty-one compounds were tentatively distinguished (twenty-one phenolic acids and their derivatives, thirty-one flavonols and nine flavones) in the negative and positive modes. Centaurea aegyptiaca demonstrated outstanding results against Hep-G2, MCF-7, HCT-116 and HELA cell lines with IC50of 12.1, 30.9, 11.7 and 19.5 ?g/mL respectively compared and doxorubicin as a reference drug. Weak antiviral activity was seen against hepatitis A virus (HAV) and no impact against herpes simplex virus type 1 (HSV 1). Conclusion: This study provides a better understanding of the chemistry of C. aegyptiaca that announces itself as a promising cytotoxic agent. 2016, African Ethnomedicines Network. All rights reserved.