Browsing by Author "Ali, Sara Bayoumi"

Now showing 1 - 3 of 3

Therapeutic effect of Nigella sativa extract on folic acid-induced acute hepatorenal injury: influences and underlying mechanisms
(Research Trends, 2023-06) Al Shawoush, Abdeljalil Mohamed; Said, Reem Sherif; Hassan, Fatma E; Ali, Sara Bayoumi; Mohamed, Ayman Saber; Elbatran, May Mohamed
Nigella sativa is utilized to treat many ailments and to maintain and improve global health as it has numerous pharmacological activities such as anti-inflammatory, antidiabetic, antimetastatic, anxiolytic, hepatoprotective and immunomodulatory. We tried to assess the disorders in the liver, the main organ for folate metabolism, and the kidney in response to high-dose folic acid (HDFA) supplementation, and we tested if the herbal Nigella sativa extract (NSE) could alter these disturbances and the likely underlying mechanisms. Eighteen adult male rats were separated into three groups: Control, HDFA and HDFA+NSE. Both kidney and liver dysfunctions induced by HDFA administration significantly improved by NSE which was supported by histological examination. Thus, NSE being an ample source of antioxidants has a hepatorenal protecting effect.
Therapeutic Effect of Trigonella foenum-graecum l Seeds Extract on Folic Acid-Induced Acute Kidney Injury
(Springer, 17/05/2022) Massoud, Ehab; Daniel, Melyssia Samy; El-Kott, Attalla; Ali, Sara Bayoumi; Morsy, Kareem; Mohamed, Ayman S; Fahmy, Sohair R
Acute kidney injury (AKI) is a serious clinical illness that produces renal failure quickly and has a high fatality rate. Fenugreek possesses anti-osteoporotic, anti-inflammatory, antipyretic, antidiabetic, and immunomodulatory activities. The current study aimed to evaluate the therapeutic efficacy of the Trigonella foenum-graecum L seeds extract (TFGE) against AKI induced by a high dose of folic acid. There were 18 male rats divided into three groups: control, folic acid, and folic acid + TFGE. Hepatorenal toxicity induced by a dose of folic acid (250 mg kg−1, i.p.) while TFGE (250 mg kg−1) administrated for seven consecutive days. The methanolic extract of TFG extract contains tannins, alkaloids, terpenoids, saponins, and phenols, while flavonoids were absent. High dose of folic acid caused increases in AST, ALT, creatinine, urea, uric acid, MDA and decreases in albumin, GSH, CAT levels. In contrast, the administration of TFGE suppresses hepatorenal toxicity and improved tissue functions and structure. TFGE, an abundant antioxidant source, has a renal protecting outcome. The current study demonstrated the therapeutic efficacy of TFGE on the liver and kidney in the treatment of gentamycin-induced hepatotoxicity. © 2022, The Author(s), under exclusive licence to The National Academy of Sciences, India.
Therapeutic potency of gallium verum extract on ethanol-induced gastric ulcer in rats
(AMG Transcend Association, 15/10/2022) Lotfy, Bassant Mohamed Mohamed; Mousa, Mohamed R; El-Shehry, Mona Samir Fawzy El-Sayed; Ahmed, Salma Hussein Abdel-Fattah; Ali, Sara Bayoumi; Al Shawoush, Abdeljalil Mohamed; Mohamed, Ayman Saber
Gallium verum, lady's bedstraw is an herbaceous annual plant belonging to the genus Rubiaceae; it possessed antioxidant, cytotoxic for cancer cells, antimicrobial, protective and endocrine effects. This work aimed to investigate the curative effects of G. verum extract on gastric ulcers following absolute ethanol administration in the healthy rat. Eighteen rats were randomly divided into three main groups; rats were fastened for 24 hours before ethanol administration. All groups except control administered ethanol (5 ml/kg body weight; orally). The rats were administrated distilled water (Ulcer group) or G. verum extract (100mg/kg) one hour later. G. verum extract caused a significant decrease in ulcer index, gastric juice volume, malondialdehyde, and nitric oxide, while gastric juice pH, glutathione, glutathione-S-transferase, and catalase increased significantly. The histological lesion score showed a significant enhancement in group G. verum compared to the ulcer group that scored the highest pathological destruction score. Immunohistochemical markers of NF-κB p65 and TNF-α showed a significant decrease in G. verum group. G. verum extract is a promising treatment modality against gastric injury through its powerful antioxidant, acid neutralizing, healing promotion, and ant- inflammation effects.