Browsing by Author "Abou-Aisha K."

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians
    (Blackwell Publishing, 2017) Abdel Rahman M.F.; Hashad I.M.; Abou-Aisha K.; Abdel Maksoud S.M.; Gad M.Z.; Biochemistry Department; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); Cairo; Egypt; Clinical Biochemistry Unit; Faculty of Pharmacy & Biotechnology; German University in Cairo; Cairo; Egypt
    The aim of the current study was to assess the link between EDN K198N SNP, ET-1 serum concentration and acute myocardial infarction (AMI) in Egyptians. The study cohort consisted of 84 patients at AMI onset and 84 age-matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA, respectively. Genotype distribution was not significantly different between AMI patients and controls (P=.8341). The mean serum ET-1 concentration of patients (13.83�0.7�pg/mL) was significantly higher than controls (7.26�0.2�pg/mL) (P<.0001). ET-1 serum concentrations did not vary significantly among various EDN genotypes in patients (P=.378) and controls (P=.6164). Hence, we conclude that EDN K198N genotypes were not related to either ET-1 concentration or incidence of early-onset AMI in Egyptians. But, AMI patients had higher ET-1 concentrations than controls. � 2016 John Wiley & Sons Australia, Ltd