Browsing by Author "Abd-Hafiz Al-Ghorafi, Mokhtar"

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    Design, synthesis, molecular docking and biological evaluation of some new thiophene derivatives as anti-cancer agents
    (ejpmr, 2019) Abd-Hafiz Al-Ghorafi, Mokhtar; Mohammed Kamal, Aliaa; Abdullah, Jalal H.; Ahmed Ali, Tawfeek; Yassin, Shada H.
    Structure-based design, synthesis and biological evaluation of newly synthesized small molecules anti-cancer agents were described. On continuation of applying scaffold hopping theory, a series of substituted 2-amino, 3- cyanothiophene based on the structural features of Sorafenib was designed, synthesized and evaluated as cytotoxic agents against MCF7 and HCT 116 cell lines. Substituting the amino group of 2-aminothiophene with different pharmacophoric groups led to discovery of two potent lead compounds IIIb and IIIc with excellent cytotoxic activity against MCF7 and HCT 116 cell lines.