Abstract:
Background: Study aims to determine the bacterial profile associated with bacterial
meningitis, their antimicrobial resistance pattern providing antimicrobial stewardship
guidance and improving the efficacy of empirical treatment. Methods: Four years caseseries retrospective study (December 2019- December 2023), of positive CSF cultures in
432 patients of various age groups and departments in Ain Shams University Hospital,
Cairo, Egypt were analyzed. Results: Predominance of Gram-negative bacteria
constituting 79.1%, while 19.6% were attributed to gram-positive in bacterial meningitis.
Notably, Klebsiella pneumoniae (K. pneumoniae) had the highest prevalence at 34%,
followed by Acinetobacter species (spp) at 19.6%. Whereas, Streptococcus pneumoniae
(S. pneumonia) exhibited a lower prevalence of 1.8%. The age group >16-50 years
demonstrated the highest prevalence at 26.6%, followed by infants aged 2 months to <1
year, with a prevalence of 23.3%. Antimicrobial resistance was predominantly against
ceftriaxone 89%, and ampicillin 87.9%. Conversely, pathogens exhibited greater
sensitivity to tobramycin (46.2%) and gentamicin (43.1%) than other antimicrobials.
Multidrug resistance was identified in 53.5% of Gram-negative bacteria. These results
highlight Gram-negative bacteria role in meningitis. Conclusion: This study revealed
significant changes in meningitis bacterial profiles, highlighting the importance of
reinforcing antimicrobial stewardship efforts to effectively combat the evolving landscape
of bacterial meningitis.