Abstract:
Stress, obesity, hormonal changes, and aging have been connected to cellulite aggravation
resulting in skin dimpled appearance, a very common painless skin disorder with a female
preponderance. Several Apiaceae plants have been traditionally used for cosmetic applications.
However, their screening for anti-cellulite potential has not been deeply investigated. In this
work, UPLC-HRMS/MS coupled with molecular networking was employed to glean a holistic
overview of the chemodiversity of the metabolome of nine Apiaceae fruits. Additionally, the
extracts were screened for in vitro antioxidant and anti-cellulite activities. Apium graveolens and
Petroselinum crispum revealed excellent free radical scavenging activity, remarkably increased
lipolysis, and decreased adipogenesis. Furthermore, apigenin and its glycosides were identified
to be the major components in both extracts, which might be responsible for the antioxidant
activity and anti-cellulite potential. Conclusively, these results signify the potent antioxidant and
anti-cellulite properties of A. graveolens and P. crispum fruit extracts, holding potential for the
development of plant derived products for cellulite management.
