Abstract:
A highly ultrasensitive sensor that relied on Cr/ZnO-NPs was developed to
detect etilefrine hydrochloride (ETF) in different matrices via a particular green voltammetric
technique. The X-ray diffraction pattern showed the nanomaterials of the polycrystalline
hexagonal structure. The energy-dispersive X-ray spectrum approved the presence of Cr3+
inside the host zinc oxide framework. The morphological and topological characteristics were
visualized using transmission electron microscopy and atomic force microscopy micrographs
describing the nanoparticles in spherical-like shape with large-surface area. The energy gap
(Eg) was evaluated from transmittance (T %) and reflectance (R %) spectra within the visible
region. The optimization study indicated that the Cr/ZnO-NP/CPE sensor has high
sensitivity, thanks to the distinctive physical and chemical properties of the fabricated
electrode. A new approach showed a great selectivity for determining ETF in different matrices
in the presence of other interferents like levodopa. Under optimal circumstances, the square-
wave voltammetry revealed a linear response to ETF from 0.01 to 10 μmol L−1 (r = 0.9996)
with quantification and detection limits of 9.11 and 2.97 nmol L−1
, respectively. Finally, the proposed approach was effectively
applied to estimate ETF in pharmaceutical dosage forms and biological fluids using simple, accurate, and selective electrochemical
electrode. The greenness profile assessment of the developed method was performed using the Eco-Scale and green analytical
procedure index. These tools indicated that the proposed method is an eco-friendly technique for the determination of ETF in
different matrices.
