Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review
Egbuna, Chukwuebuka; Patrick-Iwuanyanwu, Kingsley C; Onyeike, Eugene N; Khan, Johra; Palai, Santwana; Patel, Sandip B; Parmar, Vijaykumar K; Kushwaha8 |, Garima; Singh, Omkar; Jeevanandam, Jaison; Kumarasamy, Suresh; Uche, Chukwuemelie Zedech; Narayanan, Mathiyazhagan; Rudrapal, Mithun; Odoh, Uchenna; Chikeokwu, Ikenna; Găman, Mihnea-Alexandru; Saravanan, Kaliyaperumal; Ifemeje, Jonathan C; Ezzat, Shahira M; Olisah, Michael C; Chikwendu, Chukwudi Jude; Adedokun, Kamoru A.; Imodoye, Sikiru O.; Bello, Ibrahim O.; Twinomuhwezi, Hannington; Awuchi, Chinaza Godswill
Date issued:
2023-05
Publisher:
John Wiley and Sons Ltd
Series Info:
Food Science and Nutrition;2023;00:1–20
Type:
Article
Keywords:
acute myeloid leukemia,
,
drug discovery,
,
leukemia,
,
natural products, ج
,
secondary metabolites
Abstract:
This systematic review identified various bioactive compounds which have the po-
tential to serve as novel drugs or leads against acute myeloid leukemia. Acute myeloid
leukemia (AML) is a heterogeneous hematopoietic malignancy that arises from the
dysregulation of cell differentiation, proliferation, and cell death. The risk factors as-
sociated with the onset of AML include long-term exposure to radiation and chemi-
cals such as benzene, smoking, genetic disorders, blood disorders, advancement in
age, and others. Although novel strategies to manage AML, including a refinement
of the conventional chemotherapy regimens, hypomethylating agents, and molecu-
lar targeted drugs, have been developed in recent years, resistance and relapse re-
main the main clinical problems. In this study, three databases, PubMed/MEDLINE,
ScienceDirect, and Google Scholar, were systematically searched to identify various
bioactive compounds with antileukemic properties. A total of 518 articles were iden-
tified, out of which 59 were viewed as eligible for the current report. From the data
extracted, over 60 bioactive compounds were identified and divided into five major
groups: flavonoids, alkaloids, organosulfur compounds, terpenes, and terpenoids, and
other known and emerging bioactive compounds. The mechanism of actions of the
analyzed individual bioactive molecules differs remarkably and includes disrupting
chromatin structure, upregulating the synthesis of certain DNA repair proteins, in-
ducing cell cycle arrest and apoptosis, and inhibiting/regulating Hsp90 activities, DNA
methyltransferase 1, and histone deacetylase 1.
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