Validated HPLC Method for Simultaneous Determination of Aripiprazole and Co-Administered Clonazepam in Spiked Human Plasma

M. El-Maraghy, Christine; Salem, Hesham; M. Amer, Sawsan; Nebsen, Marianne

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dc.contributor.author	M. El-Maraghy, Christine
dc.contributor.author	Salem, Hesham
dc.contributor.author	M. Amer, Sawsan
dc.contributor.author	Nebsen, Marianne
dc.date.accessioned	2019-10-26T09:50:46Z
dc.date.available	2019-10-26T09:50:46Z
dc.date.issued	2017
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dc.identifier.other	https://doi.org/10.18576/jpac/030108
dc.identifier.uri	https://t.ly/xNwJq
dc.description	MSA Google Scholar
dc.description.abstract	A sensitive and selective high performance liquid chromatographic method was developed and validated for the simultaneous quantification of Aripiprazole and co-administered Clonazepam in spiked human plasma. Aripiprazole, Clonazepam and the internal standard Citalopram were extracted from plasma and analyzed on a reversed-phase C18 column using a mobile phase consisting of acetonitrile and 0.05M potassium dihydrogen orthophosphate (pH= 3.6) in a ratio of (40: 60, v/v). The ultraviolet (UV) detection was at 220 nm. The method was linear over concentration range (20- 1000 ng mL-1 ) for both drugs. The method is very simple and allows obtaining a very good recovery of the analytes.	en_US
dc.description.sponsorship	Journal of Pharmaceutical and Applied Chemistry An International Journal	en_US
dc.language.iso	en	en_US
dc.publisher	Journal of Pharmaceutical and Applied Chemistry An International Journal	en_US
dc.relation.ispartofseries	J. Pharm. Appl. Chem;3, 1, 57-61
dc.subject	University of Aripiprazole	en_US
dc.subject	Clonazepam	en_US
dc.title	Validated HPLC Method for Simultaneous Determination of Aripiprazole and Co-Administered Clonazepam in Spiked Human Plasma	en_US
dc.type	Article	en_US
dc.identifier.doi	https://doi.org/10.18576/jpac/030108
dc.Affiliation	October University for modern sciences and Arts (MSA)