Publisher:Journal of Pharmaceutical and Applied Chemistry An International Journal
Series Info:J. Pharm. Appl. Chem;3, 1, 57-61
Type:Article
Keywords:University of Aripiprazole
,
Clonazepam
Abstract:
A sensitive and selective high performance liquid chromatographic method was developed and validated for the
simultaneous quantification of Aripiprazole and co-administered Clonazepam in spiked human plasma. Aripiprazole,
Clonazepam and the internal standard Citalopram were extracted from plasma and analyzed on a reversed-phase C18
column using a mobile phase consisting of acetonitrile and 0.05M potassium dihydrogen orthophosphate (pH= 3.6) in a
ratio of (40: 60, v/v). The ultraviolet (UV) detection was at 220 nm. The method was linear over concentration range (20-
1000 ng mL-1
) for both drugs. The method is very simple and allows obtaining a very good recovery of the analytes.
