Abstract:
The bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharma-
cophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole
nuclei have been very attractive to researchers for drug design, synthesis, and the study of their
potential activity towards a variety of diseases, including microbial and viral infections, cancer,
diabetes, pain, and inflammation. This work is an up-to-date comparative study that identifies the
differences between 1,3,4-thiadiazoles and 1,3,4-oxadiazoles concerning their methods of synthesis
from different classes of starting compounds under various reaction conditions, as well as their
biological activities and structure–activity relationship.
