Abstract:
Aging has become a concern for many people, especially women. Given that high-quality anti-aging
products are of high cost; it has imperative to search for other economical sources. Essential oils
are frequently used in cosmetics products due to a wide range of biological activities as well as their
pleasant odor. The current study aimed to investigate the biochemical efect of the cosmetic potential
of selected Apiaceous essential oils, traditionally used for skincare, by evaluating their anti-wrinkle
activity. It is worth noting that, coriander essential oil showed the highest collagenase, elastase,
tyrosinase, and hyaluronidase inhibitory activities compared to other Apiaceous oils (fennel, anise,
and cumin). GC–MS proved that coriander essential oil showed a very high level of oxygenated
monoterpenes, with linalool (81.29%) as the most abundant constituent. Intriguingly, coriander oil
cream and Coriander Essential Oil-loaded Lipid Nanoparticles (CEOLNs) formulations attenuated
in vivo UV-induced skin photoaging that was manifested by signifcantly decreased MDA, COX-2, PGE-
2, MMP-1, JNK, and AP-1 levels. Moreover, these pharmaceutical dosage forms signifcantly increased
skin collagen content compared to UV-injured group. Also, coriander essential oil signifcantly
increased TGFβ, TGFβII, and SMAD3 protein expression levels compared to UV-injured group. In
conclusion, the pharmaceutical dosage forms of coriander oil possess anti-wrinkle activities that could
have an auspicious role in amending extrinsic aging.
