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Faculty Of Pharmacy Research Paper: Recent submissions

Now showing items 1-20 of 1121

A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma

Assal, Reem A; Elemam, Noha M; Mekky, Radwa Y; Attia, Abdelrahman A; Soliman, Aya Hesham; Gomaa, Asmaa Ibrahim; Efthimiadou, Eleni K; Braoudaki, Maria; Fahmy, Sherif Ashraf; Youness, Rana A (Neoplasia Press, Inc, 2024-04)

Tumor microenvironment is an intricate web of stromal and immune cells creating an immune suppressive cordon around the tumor. In hepatocellular carcinoma (HCC), Tumor microenvironment is a formidable barrier towards novel ...
Plant-Polyphenol-Mediated Synthesis of Magnetic Biocompatible Iron Oxide Nanoparticles for Diagnostic Imaging and Management of Neurodegenerative Diseases

Abdelmonem, Mohamed; Albert, Emmellie Laura; Alhadad, Maha A; Abdullah, Che Azurahanim Che (Andover House, Inc, 2024-04)

Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), and glioblastoma tumors (GB), represent a spectrum of disorders characterized by progressive neuronal degeneration. This ...
Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights

Ezzat, Shahira M; Merghany, Rana M; Abdel Baki, Passent M; Abdelrahim, Nariman Ali; Osman, Sohaila M; Salem, Mohamed A; Peña-Corona, Sheila I; Cortés, Hernán; Kiyekbayeva, Lashyn; Leyva-Gómez, Gerardo; Sharifi-Rad, Javad; Calina, Daniela (Wiley-VCH Verlag, 2024-04)

Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of ...
Lipid nanocapsules: A Novel Strategy for Brain Targeting via Nasal Administration

IBRAHIM, Mennatullah; BASALIOUS, Emad; El-NABARAWI, Mohamed; MAKHLOUF, Amal (Marmara University, 2024-03)

In spite of the great advance in drug delivery systems (DDSs) for the control of the neurological disorders like Alzheimer's disease, Parkinson's disease, epilepsy and seizures, yet there is a demand for innovative DDSs ...
Evaluation and formulation of Spirulina platensis proteins for potential applications in hair care products

Elkady, Omar A; Mannaa, Islam M; El Bishbishy, Mahitab H (Springer Nature, 2024-03)

Spirulina platensis, a blue-green algae belonging to family Phormidiaceae, is well-known for its unique nutritional profle and high protein content. This study aims to isolate its proteins, formulate them into a cream ...
Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients

., Azza Gaber Antar Farag a, Eman Abd-Elfatah Badr b, Banan Mohamed Gamal Abd-Elaty c, Nada Farag Elnaidany d, Mai Medhat Mohamed Ghanem a, (Elsevier BV, 2024-03)

Background: Alopecia Areata (AA) is an acquired autoimmune form of non-scarring hair loss. Adiponectin and its gene polymorphism were related to many autoimmune disorders. Objective: Assessment of adiponectin serum levels ...
Emergence of carbapenem resistant gram-negative pathogens with high rate of colistin resistance in Egypt: A cross sectional study to assess resistance trends during the COVID-19 pandemic

Afify, Fatma A; Shata, Ahmed H; Aboelnaga, Nirmeen; Osama, Dina; Elsayed, Salma W; Saif, Nehal A; Mouftah, Shaimaa F; Shawky, Sherine M; Mohamed, Ahmed A; Loay, Omar; Elhadidy, Mohamed (Academy of Scientific Research and Technology, 2024-03)

The current study investigated the temporal phenotypic and genotypic antimicrobial resistance (AMR) trends among multi‐drug resistant and carbapenem‐resistant Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas ...
Atorvastatin loaded lecithin‑coated zein nanoparticles based thermogel for the intra‑articular management of osteoarthritis: in‑silico, in‑vitro, and in‑vivo studies

Elgendy, Heba Amin ; Makky, Amna M. A; Elakkad, Yara E; Awad, Heba H; El Hassab, Mahmoud A; Younes, Nihal Farid (Springer Netherlands, 2024-02)

Purpose Up-to-date literature ofers limited data about utilizing atorvastatin calcium (ATV) as a promising chondroprotective agent in osteoarthritis (OA). So, this study aims to develop a depot intra-articular (IA) ...
Development of antifungal fibrous ocular insert using freeze‑drying technique

Teba, Hoda E; Khalil, Islam A; Gebreel, Rana M; Fahmy, Lamiaa I; El Sorogy, Heba M (Springer Publishing Company, 2024-01)

Candida species is one of the pathogenic fungi of the eye responsible for keratitis that frequently causes vision impairment and blindness. Effective treatment requires long-term use of antifungal drugs, which is opposed ...
Ezetimibe-Loaded Nanostructured Lipid Carrier for Oral Delivery: Response Surface Methodology; In Vitro Characterization and Assessing the Antihyperlipidemic Effect in Rats

Elkhayat, Dalia; Abdelmalak, Nevine S; Amer, Reham; Awad, Heba H (American Chemical Society, 2024-02)

Among the independent risk factors for the occurrence of cardiovascular diseases like atherosclerosis is hyperlipidemia. To decrease cardiovascular events and patient mortality, antihyperlipidemia therapy is crucial. ...
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen

Amer, Mai A; Darwish, Manal M; Soliman, Noha S; Amin, Heba M (Frontiers Media S.A., 2024-02)

Coagulase-negative staphylococci (CoNS) are a group of gram-positive staphylococcal species that naturally inhabit the healthy human skin and mucosa. The clinical impact of CoNS-associated infections has recently ...
Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study

Ibrahim, Mennatullah M; Basalious, Emad B; El‑Nabarawi, Mohamed A; Makhlouf, Amal IA; Sayyed, Marwa Eid ; Ibrahim, Ismail Taha (Springer Publishing Company, 2024-01)

Mirtazapine (MZPc) is an antidepressant drug which is approved by the FDA. It has low bioavailability, which is only 50%, in spite of its rapid absorption when orally administered owing to high first-pass metabolism. ...
Chewing gum containing repaglinide solid dispersion using mesoporous silica nanoparticles for management of diabetes mellitus: In-vitro evaluation and clinical appraisal

Badawi, Noha M; Amer, Reham I; Attia, Dalia A; Fayez, Ahmed M; Dawoud, Marwa H.S (Editions de Sante, 2024-02)

The current study aimed to formulate repaglinide solid dispersion via mesoporous silica nanoparticles (R-MSNs) as a carrier in an attempt to enhance drug solubility. Then incorporation of it in a medicated chewing gum ...
Green and white-assessed validated chromatographic methods for Ondansetron purity testing in its pharmaceutical formulations; in silico toxicity profiling of impurities

El-Maraghy, Christine M; Nour, Mai S; ELbalkiny, Heba T (Elsevier Inc, 2024-02)

Drug impurities are seen as a crucial threat to drug safety, specifically when dealing with mutagenic/ toxic impurities. Here, we present LC-MS/MS and HPTLC-densitometric methods for simultaneous quantification of Ondansetron ...
Exploiting response surface D‑optimal design study for preparation and optimization of spanlastics loaded with miconazole nitrate as a model antifungal drug for topical application

Ibrahim, Mervat Shafik ; Elkady, Omar A; Amer, Mai A; Noshi, Shereen H (Springer New York, 2023-12)

Purpose Skin fungal infections are widely spreading worldwide and are considered a main cause of skin, mucous membranes, and systemic diseases. In an approach to enhance the topical delivery of miconazole nitrate (MZN) ...
Investigations of new N1-substituted pyrazoles as anti-inflammatory and analgesic agents having COX inhibitory activity

Said, Mona F; George, Riham F; Fayed, Walid; Soliman, Ahmed A F; Refaey, Rana H (Future Science, 2024-01)

Background: The search is ongoing for ideal anti-inflammatory and analgesic agents with promising potency and reasonable selectivity. Methods: New N1-substituted pyrazoles with or without an acetamide linkage ...
Preparation and in vivo evaluation of nano sized cubosomal dispersion loaded with Ruta graveolens extracts as a novel approach to reduce asthma-mediated lung inflammation

Alyami, Mohammad H; Hamdan, Dalia I; Khalil, Heba M.A; Orabi, Mohamed A.A; Aborehab, Nora M; Osama, Nada; Abdelhafez, Mai M; Al-Mahallawi, Abdulaziz Mohsen; Alyami, Hamad S (King Saud University, 2024-02)

Asthma is a chronic disease affecting people of all ages. Asthma medications are associated with adverse effects restricting their long-term usage, demanding newer alternative therapies. This study aimed to investigate ...
Comparative genomic analysis of strong biofilm-forming Klebsiella pneumoniae isolates uncovers novel ISEcp1-mediated chromosomal integration of a full plasmid-like sequence

Hamed, Samira M; Mohamed, Hend O; Ashour, Hossam M; Fahmy, Lamiaa I (Taylor and Francis Ltd, 2024-01)

Background: The goal of the current study was to elucidate the genomic background of biofilm formation in Klebsiella pneumoniae. Methods: Clinical isolates were screened for biofilm formation using the crystal violet assay. ...
Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology

Elemam, Noha M; Mekky, Radwa Y; Rashid, Gowhar; Braoudaki, Maria; Youness, Rana A (Cambridge University Press, 2024-01)

The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion ...
Guidelines for accurate application of green and white analytical concepts: Merits Versus demerits with insights of significant milestones of assessment tools applied for antiviral drugs

Saleh, Sarah S; Obaydo, Reem H; El Hamd, Mohamed A; Rostom, Yasmin; Mohamed, Dalia; Lotfy, Hayam M (Elsevier Inc, 2024-01)

In recent years, there has been a growing focus in analytical research on the ecological and sustainable aspects of analytical methodologies. However, it is necessary to apply the relevant metrics to evaluate the ...

Now showing items 1-20 of 1121

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