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| dc.contributor.author | Mohareb R.M. | |
| dc.contributor.author | El-Arab E.E. | |
| dc.contributor.author | El-Sharkawy K.A. | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | October University for Modern Sciences and Arts | |
| dc.contributor.other | Elwahaat Road | |
| dc.contributor.other | October City | |
| dc.contributor.other | Egypt; Faulty of Science | |
| dc.contributor.other | Chemistry Department | |
| dc.contributor.other | Cairo University | |
| dc.contributor.other | Egypt; National Organization of Drug Control and Research (NODCAR) | |
| dc.contributor.other | P.O. 29 | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-25T19:58:34Z | |
| dc.date.available | 2020-01-25T19:58:34Z | |
| dc.date.issued | 2009 | |
| dc.identifier.issn | 368709 | |
| dc.identifier.other | https://doi.org/10.3797/scipharm.0901-20 | |
| dc.identifier.uri | https://t.ly/0Mge3 | |
| dc.description | Scopus | |
| dc.description.abstract | The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2-10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs. � Mohareb et al.; licensee �sterreichische Apotheker-Verlagsgesellschaft m. b. H. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=22212&tip=sid&clean=0 | |
| dc.language.iso | English | en_US |
| dc.relation.ispartofseries | Scientia Pharmaceutica | |
| dc.relation.ispartofseries | 77 | |
| dc.subject | Antimicrobial | en_US |
| dc.subject | Pyridine | en_US |
| dc.subject | Thiazole | en_US |
| dc.subject | Thiophene | en_US |
| dc.subject | 2 cyano n '(1 furan 2 ylethylidene) 3 (4 methoxyphenyl)prop 2 enehydrazide | en_US |
| dc.subject | 2 cyano n (1 furan 2 ylethylidene) 3 phenylprop 2 enehydrazide | en_US |
| dc.subject | 2 cyano n' (1 furan 2 ylethylidene) 2 (phenylhydrazono)acetohydrazide | en_US |
| dc.subject | 2 cyano n' (1 furan 2 ylethylidene) 2 [(4 methoxyphenyl)hydrazono]acetohydrazide | en_US |
| dc.subject | 2 cyano n' (1 furan 2 ylethylidene) 2 [(4 methylphenyl)hydrazono]acetohydrazide | en_US |
| dc.subject | 3 (4 chlorophenyl) 2 cyano n' (1 furan 2 ylethylidene)prop 2 enehydrazide | en_US |
| dc.subject | 3 amino n' (1 furan 2 ylethylidene) 4,5,6,7 tetrahydro 1 benzothiophene 2 carbohydrazide | en_US |
| dc.subject | 3,5 diamino 4 cyano n' (1 furan 2 ylethylidene)thiophene 2 carbohydrazide | en_US |
| dc.subject | 4 amino n' (1 furan 2 ylethylidene) 3 phenyl 2 thioxo 2,3 dihydro 1,3 thiazole 5 carbohydrazide | en_US |
| dc.subject | 4,6 diamino 1 [(1 furan 2 ylethylidene)amino] 2 oxo 1,2 dihydropyridine 3 carbonitrile | en_US |
| dc.subject | 6 amino 1 [(1 furan 2 ylethylidene)amino] 2 oxo 4 phenyl 1,2 dihydropyridine 3,5 dicarbonitrile | en_US |
| dc.subject | acetic acid derivative | en_US |
| dc.subject | ampicillin | en_US |
| dc.subject | antiinfective agent | en_US |
| dc.subject | coumarin derivative | en_US |
| dc.subject | cycloheximide | en_US |
| dc.subject | ethyl 2 amino 5 cyano 1 [(1 furan 2 ylethylidene)amino] 6 oxo 4 phenyl 1,6 dihydropyridine 3 carboxylate | en_US |
| dc.subject | ethyl 2,4 diamino 5 [[2 (1 furan 2 ylethylidene)hydrazino]carbonyl]thiophene 3 carboxylic acid | en_US |
| dc.subject | ethyl 4 amino 5 cyano 1 [(1 furan 2 ylethylidene)amino] 6 oxo 1,6 dihydropyridine 2 carboxylic acid | en_US |
| dc.subject | furan derivative | en_US |
| dc.subject | hydrazide derivative | en_US |
| dc.subject | hydrazone derivative | en_US |
| dc.subject | n' (1 furan 2 ylethylidene) 2 oxo 2h chromene 3 carbohydrazide | en_US |
| dc.subject | pyridine derivative | en_US |
| dc.subject | thiazole derivative | en_US |
| dc.subject | thiophene derivative | en_US |
| dc.subject | unclassified drug | en_US |
| dc.subject | antimicrobial activity | en_US |
| dc.subject | article | en_US |
| dc.subject | Bacillus cereus | en_US |
| dc.subject | Bacillus subtilis | en_US |
| dc.subject | Caenorhabditis elegans | en_US |
| dc.subject | chemical reaction | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | drug synthesis | en_US |
| dc.subject | Escherichia coli | en_US |
| dc.subject | minimum inhibitory concentration | en_US |
| dc.subject | nonhuman | en_US |
| dc.title | The reaction of cyanoacetic acid hydrazide with 2-acetylfuran: Synthesis of coumarin, pyridine, thiophene and thiazole derivatives with potential antimicrobial activities | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.3797/scipharm.0901-20 | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
