The reaction of cyanoacetic acid hydrazide with 2-acetylfuran: Synthesis of coumarin, pyridine, thiophene and thiazole derivatives with potential antimicrobial activities

Mohareb R.M.; El-Arab E.E.; El-Sharkawy K.A.

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The reaction of cyanoacetic acid hydrazide with 2-acetylfuran: Synthesis of coumarin, pyridine, thiophene and thiazole derivatives with potential antimicrobial activities

Mohareb R.M.; El-Arab E.E.; El-Sharkawy K.A.

Full Text link: https://t.ly/0Mge3

Date issued: 2009

Scientific Journal Rankings: Click Here

Doi: https://doi.org/10.3797/scipharm.0901-20

Series Info: Scientia Pharmaceutica
77

Type: Article

Keywords: Antimicrobial , Pyridine , Thiazole , Thiophene , 2 cyano n '(1 furan 2 ylethylidene) 3 (4 methoxyphenyl)prop 2 enehydrazide , 2 cyano n (1 furan 2 ylethylidene) 3 phenylprop 2 enehydrazide , 2 cyano n' (1 furan 2 ylethylidene) 2 (phenylhydrazono)acetohydrazide , 2 cyano n' (1 furan 2 ylethylidene) 2 [(4 methoxyphenyl)hydrazono]acetohydrazide , 2 cyano n' (1 furan 2 ylethylidene) 2 [(4 methylphenyl)hydrazono]acetohydrazide , 3 (4 chlorophenyl) 2 cyano n' (1 furan 2 ylethylidene)prop 2 enehydrazide , 3 amino n' (1 furan 2 ylethylidene) 4,5,6,7 tetrahydro 1 benzothiophene 2 carbohydrazide , 3,5 diamino 4 cyano n' (1 furan 2 ylethylidene)thiophene 2 carbohydrazide , 4 amino n' (1 furan 2 ylethylidene) 3 phenyl 2 thioxo 2,3 dihydro 1,3 thiazole 5 carbohydrazide , 4,6 diamino 1 [(1 furan 2 ylethylidene)amino] 2 oxo 1,2 dihydropyridine 3 carbonitrile , 6 amino 1 [(1 furan 2 ylethylidene)amino] 2 oxo 4 phenyl 1,2 dihydropyridine 3,5 dicarbonitrile , acetic acid derivative , ampicillin , antiinfective agent , coumarin derivative , cycloheximide , ethyl 2 amino 5 cyano 1 [(1 furan 2 ylethylidene)amino] 6 oxo 4 phenyl 1,6 dihydropyridine 3 carboxylate , ethyl 2,4 diamino 5 [[2 (1 furan 2 ylethylidene)hydrazino]carbonyl]thiophene 3 carboxylic acid , ethyl 4 amino 5 cyano 1 [(1 furan 2 ylethylidene)amino] 6 oxo 1,6 dihydropyridine 2 carboxylic acid , furan derivative , hydrazide derivative , hydrazone derivative , n' (1 furan 2 ylethylidene) 2 oxo 2h chromene 3 carbohydrazide , pyridine derivative , thiazole derivative , thiophene derivative , unclassified drug , antimicrobial activity , article , Bacillus cereus , Bacillus subtilis , Caenorhabditis elegans , chemical reaction , controlled study , drug synthesis , Escherichia coli , minimum inhibitory concentration , nonhuman

Abstract:

The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2-10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs. � Mohareb et al.; licensee �sterreichische Apotheker-Verlagsgesellschaft m. b. H.