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| dc.contributor.author | Aborehab N.M. | |
| dc.contributor.author | El Bishbishy M.H. | |
| dc.contributor.author | Refaiy A. | |
| dc.contributor.author | Waly N.E. | |
| dc.contributor.other | MSA University | |
| dc.contributor.other | Department of Biochemistry | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | Giza | |
| dc.contributor.other | 11787 | |
| dc.contributor.other | Egypt; MSA University | |
| dc.contributor.other | Department of Pharmacognosy | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | Giza | |
| dc.contributor.other | 11787 | |
| dc.contributor.other | Egypt; Assiut University | |
| dc.contributor.other | Department of Pathology Faculty of Medicine | |
| dc.contributor.other | Assiut | |
| dc.contributor.other | 71515 | |
| dc.contributor.other | Egypt; Department of Physiology | |
| dc.contributor.other | Faculty of Medicine | |
| dc.contributor.other | Helwan University | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | 11795 | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:41:13Z | |
| dc.date.available | 2020-01-09T20:41:13Z | |
| dc.date.issued | 2017 | |
| dc.identifier.issn | 14726882 | |
| dc.identifier.other | https://doi.org/10.1186/s12906-017-2002-y | |
| dc.identifier.other | PubMed ID 29166937 | |
| dc.identifier.uri | https://t.ly/6xMX1 | |
| dc.description | Scopus | |
| dc.description.abstract | Background: Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model. Methods: Thirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Ginger and curcumin was orally administered at doses of 200 and 400mg/kg (F200 and F400). Serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1?) and superoxide dismutase activity (SOD) were measured using ELISA. The composition of the herbal formula hydro-ethanolic extract was characterized using UPLC-ESI-MS. Histopathological changes in injected joints was examined using routine histopathology. Statistical analysis was performed using one-way ANOVA. Results: Serum levels of COMP, HA, MPO, MDA, and IL-1? were significantly decreased in F 200, F 400 and V groups when compared to OA group (P value <0.0001). On the other hand SOD levels were significantly elevated in treated groups compared to OA groups (P value <0.0001). Conclusions: The ginger/curcumin at 1:1 had chondroprotective effect via anti-inflammatory and antioxidant effect in rat OA model. Further pharmacological and clinical studies are needed to evaluate this effect. � 2017 The Author(s). | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=34441&tip=sid&clean=0 | |
| dc.language.iso | English | en_US |
| dc.publisher | BioMed Central Ltd. | en_US |
| dc.relation.ispartofseries | BMC Complementary and Alternative Medicine | |
| dc.relation.ispartofseries | 17 | |
| dc.subject | COMP | en_US |
| dc.subject | Curcumin | en_US |
| dc.subject | Ginger | en_US |
| dc.subject | HA | en_US |
| dc.subject | IL-1? | en_US |
| dc.subject | MDA | en_US |
| dc.subject | MPO | en_US |
| dc.subject | Osteoarthritis | en_US |
| dc.subject | alcohol | en_US |
| dc.subject | cartilage oligomeric matrix protein | en_US |
| dc.subject | curcumin | en_US |
| dc.subject | ginger extract | en_US |
| dc.subject | hyaluronic acid | en_US |
| dc.subject | interleukin 1beta | en_US |
| dc.subject | iodoacetic acid | en_US |
| dc.subject | malonaldehyde | en_US |
| dc.subject | myeloperoxidase | en_US |
| dc.subject | superoxide dismutase | en_US |
| dc.subject | cartilage oligomeric matrix protein | en_US |
| dc.subject | curcumin | en_US |
| dc.subject | hyaluronic acid | en_US |
| dc.subject | interleukin 1beta | en_US |
| dc.subject | malonaldehyde | en_US |
| dc.subject | peroxidase | en_US |
| dc.subject | plant extract | en_US |
| dc.subject | protective agent | en_US |
| dc.subject | superoxide dismutase | en_US |
| dc.subject | animal experiment | en_US |
| dc.subject | animal model | en_US |
| dc.subject | animal tissue | en_US |
| dc.subject | antiinflammatory activity | en_US |
| dc.subject | antioxidant activity | en_US |
| dc.subject | Article | en_US |
| dc.subject | chondroprotection | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | drug effect | en_US |
| dc.subject | drug mechanism | en_US |
| dc.subject | Egypt | en_US |
| dc.subject | enzyme activity | en_US |
| dc.subject | enzyme linked immunosorbent assay | en_US |
| dc.subject | histopathology | en_US |
| dc.subject | liquid chromatography-mass spectrometry | en_US |
| dc.subject | male | en_US |
| dc.subject | nonhuman | en_US |
| dc.subject | osteoarthritis | en_US |
| dc.subject | protein blood level | en_US |
| dc.subject | randomized controlled trial | en_US |
| dc.subject | rat | en_US |
| dc.subject | animal | en_US |
| dc.subject | blood | en_US |
| dc.subject | chemistry | en_US |
| dc.subject | disease model | en_US |
| dc.subject | ginger | en_US |
| dc.subject | metabolism | en_US |
| dc.subject | Animals | en_US |
| dc.subject | Cartilage Oligomeric Matrix Protein | en_US |
| dc.subject | Curcumin | en_US |
| dc.subject | Disease Models, Animal | en_US |
| dc.subject | Ginger | en_US |
| dc.subject | Hyaluronic Acid | en_US |
| dc.subject | Interleukin-1beta | en_US |
| dc.subject | Male | en_US |
| dc.subject | Malondialdehyde | en_US |
| dc.subject | Osteoarthritis | en_US |
| dc.subject | Peroxidase | en_US |
| dc.subject | Plant Extracts | en_US |
| dc.subject | Protective Agents | en_US |
| dc.subject | Superoxide Dismutase | en_US |
| dc.title | A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.1186/s12906-017-2002-y | |
| dc.identifier.doi | PubMed ID 29166937 | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
