Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma

Ali M.A.; Matboli M.; El-Khazragy N.; Saber O.; El-Nakeep S.; Abdelzaher H.M.; Shafei A.E.-S.; Mostafa R.

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dc.contributor.author	Ali M.A.
dc.contributor.author	Matboli M.
dc.contributor.author	El-Khazragy N.
dc.contributor.author	Saber O.
dc.contributor.author	El-Nakeep S.
dc.contributor.author	Abdelzaher H.M.
dc.contributor.author	Shafei A.E.-S.
dc.contributor.author	Mostafa R.
dc.contributor.other	Department of Biomedical Research
dc.contributor.other	Armed Forces College of Medicine (AFCM)
dc.contributor.other	Cairo
dc.contributor.other	11774
dc.contributor.other	Egypt; Department of Medical Biochemistry and Molecular Biology
dc.contributor.other	Ain Shams Faculty of Medicine Research Center (Masri)11778
dc.contributor.other	Egypt; Department of Clinical Pathology
dc.contributor.other	Oncology Diagnostic Unit
dc.contributor.other	Faculty of Medicine
dc.contributor.other	Ain Shams University
dc.contributor.other	Cairo
dc.contributor.other	11778
dc.contributor.other	Egypt; Armed Forces College of Medicine (AFCM)
dc.contributor.other	Cairo
dc.contributor.other	11774
dc.contributor.other	Egypt; Hepatology and Gastroenterology Unit
dc.contributor.other	Internal Medicine Department
dc.contributor.other	Faculty of Medicine
dc.contributor.other	Ain Shams University
dc.contributor.other	Cairo
dc.contributor.other	11778
dc.contributor.other	Egypt; Faculty of Biotechnology
dc.contributor.other	October University for Modern Sciences and Arts
dc.contributor.other	Cairo
dc.contributor.other	12585
dc.contributor.other	Egypt
dc.date.accessioned	2020-01-09T20:40:58Z
dc.date.available	2020-01-09T20:40:58Z
dc.date.issued	2018
dc.identifier.issn	17520363
dc.identifier.other	https://doi.org/10.2217/bmm-2017-0273
dc.identifier.other	PubMedID29441798
dc.identifier.uri	https://t.ly/q2rjD
dc.description	Scopus
dc.description.abstract	Aim: We aimed to examine the statistical association between serum expression of miRNA 661 (miR-661) and ATG-4B mRNA and hepatocellular carcinoma (HCC) based on in silico data analysis followed by clinical validation. Patients & methods: Quantitative reverse-transcriptase real-time PCR was used to examine the expression of miR-661 and ATG-4B mRNA in the sera of HCC patients versus control. Results: The expression of miR-661 and ATG-4B mRNA was positive in 97.14 and 77.14%, respectively, in HCC patients. The survival analysis showed that ATG-4B mRNA was an independent prognostic factor. Conclusion: Our data are the first report of its kind regarding the considerable clinical significance of miR-661 and ATG-4B mRNA in HCC patients. � 2018 2018 Future Medicine Ltd.	en_US
dc.language.iso	English	en_US
dc.publisher	Future Medicine Ltd.	en_US
dc.relation.ispartofseries	Biomarkers in Medicine
dc.relation.ispartofseries	12
dc.subject	ATG-4B	en_US
dc.subject	bioinformatics	en_US
dc.subject	biomarkers	en_US
dc.subject	hepatocellular carcinoma	en_US
dc.subject	miR-661	en_US
dc.subject	prognosis	en_US
dc.subject	alanine aminotransferase	en_US
dc.subject	bilirubin	en_US
dc.subject	cysteine proteinase	en_US
dc.subject	messenger RNA	en_US
dc.subject	microRNA	en_US
dc.subject	microRNA 661	en_US
dc.subject	protein ATG 4	en_US
dc.subject	unclassified drug	en_US
dc.subject	ATG4B protein, human	en_US
dc.subject	autophagy related protein	en_US
dc.subject	cysteine proteinase	en_US
dc.subject	messenger RNA	en_US
dc.subject	microRNA	en_US
dc.subject	MIRN661 microRNA, human	en_US
dc.subject	tumor marker	en_US
dc.subject	adult	en_US
dc.subject	alanine aminotransferase blood level	en_US
dc.subject	area under the curve	en_US
dc.subject	Article	en_US
dc.subject	ATG4 B gene	en_US
dc.subject	bilirubin blood level	en_US
dc.subject	cancer prognosis	en_US
dc.subject	cancer staging	en_US
dc.subject	cancer survival	en_US
dc.subject	Child Pugh score	en_US
dc.subject	disease marker	en_US
dc.subject	female	en_US
dc.subject	gene	en_US
dc.subject	gene expression	en_US
dc.subject	human	en_US
dc.subject	liver cell carcinoma	en_US
dc.subject	liver cirrhosis	en_US
dc.subject	major clinical study	en_US
dc.subject	male	en_US
dc.subject	protein blood level	en_US
dc.subject	receiver operating characteristic	en_US
dc.subject	reverse transcription polymerase chain reaction	en_US
dc.subject	sensitivity and specificity	en_US
dc.subject	survival rate	en_US
dc.subject	blood	en_US
dc.subject	case control study	en_US
dc.subject	genetics	en_US
dc.subject	liver cell carcinoma	en_US
dc.subject	liver tumor	en_US
dc.subject	metabolism	en_US
dc.subject	middle aged	en_US
dc.subject	pathology	en_US
dc.subject	prognosis	en_US
dc.subject	upregulation	en_US
dc.subject	Area Under Curve	en_US
dc.subject	Autophagy-Related Proteins	en_US
dc.subject	Biomarkers, Tumor	en_US
dc.subject	Carcinoma, Hepatocellular	en_US
dc.subject	Case-Control Studies	en_US
dc.subject	Cysteine Endopeptidases	en_US
dc.subject	Female	en_US
dc.subject	Humans	en_US
dc.subject	Liver Neoplasms	en_US
dc.subject	Male	en_US
dc.subject	MicroRNAs	en_US
dc.subject	Middle Aged	en_US
dc.subject	Neoplasm Staging	en_US
dc.subject	Prognosis	en_US
dc.subject	RNA, Messenger	en_US
dc.subject	ROC Curve	en_US
dc.subject	Up-Regulation	en_US
dc.title	Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma	en_US
dc.type	Article	en_US
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dcterms.source	Scopus
dc.identifier.doi	https://doi.org/10.2217/bmm-2017-0273
dc.identifier.doi	PubMedID29441798
dc.Affiliation	October University for modern sciences and Arts (MSA)