JavaScript is disabled for your browser. Some features of this site may not work without it.
| dc.contributor.author | Aborehab N.M. | |
| dc.contributor.author | Waly N.E. | |
| dc.contributor.other | Department of Biochemistry | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | October University for Modern Sciences and Arts (MSA University)6th October Giza 12611 | |
| dc.contributor.other | Egypt; Department of Physiology | |
| dc.contributor.other | Faculty of Medicine | |
| dc.contributor.other | Helwan University | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | 11795 | |
| dc.contributor.other | Egypt; Department of Medical Education | |
| dc.contributor.other | Creighton School of Medicine | |
| dc.contributor.other | Omaha | |
| dc.contributor.other | NE zip 68175 | |
| dc.contributor.other | United States | |
| dc.date.accessioned | 2020-01-09T20:40:43Z | |
| dc.date.available | 2020-01-09T20:40:43Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 22147500 | |
| dc.identifier.other | https://doi.org/10.1016/j.toxrep.2019.05.008 | |
| dc.identifier.other | PubMed ID : | |
| dc.identifier.uri | https://t.ly/W536X | |
| dc.description | Scopus | |
| dc.description.abstract | In this study, we investigated possible hepato-protective effects of N. Sativa, P. Ginseng, and C. Sempervirens in Aflatoxin B1 (AFB-1) induced hepatocellular carcinoma rat model. Fifty-four male albino rats were randomly assigned to experimental groups. Alcoholic extracts of aforementioned herbs were administered orally for 28 days at different doses. IL-6, hs-CRP, MDA, SOD and NFE2L2 were determined using ELISA. Histopathological changes in treated groups were examined. Herbal treatment significantly reduced IL-6, hs-CRP, and MDA (P < 0.001) whereas it significantly increased SOD (p < 0.001). C. Sempervirens 600 and N. Sativa 1000 increased NFE2L2 level compared to P. Ginseng 500 group (P value<0.01). Histopathological evaluation of treated groups showed different grades of healing of the liver. This study confirms a beneficial hepatoprotective effect for aforementioned herbal extracts orally administered in rat model of AFB1 induced HCC. This effect is putatively mediated via modulation of inflammatory cytokines as well as amelioration of oxidative stress. � 2019 | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=21100367469&tip=sid&clean=0 | |
| dc.language.iso | English | en_US |
| dc.publisher | Elsevier Inc. | en_US |
| dc.relation.ispartofseries | Toxicology Reports | |
| dc.relation.ispartofseries | 6 | |
| dc.subject | جامعة أكتوبر للعلوم الحديثة والآداب | |
| dc.subject | MSA University | |
| dc.subject | University for Modern Sciences and Arts | |
| dc.subject | October University for Modern Sciences and Arts | |
| dc.subject | C. Sempervirens | en_US |
| dc.subject | HCC | en_US |
| dc.subject | IL-6 | en_US |
| dc.subject | N. Sativa | en_US |
| dc.subject | NFE2L2 | en_US |
| dc.subject | P. Ginseng | en_US |
| dc.subject | alanine aminotransferase | en_US |
| dc.subject | alpha fetoprotein | en_US |
| dc.subject | aspartate aminotransferase | en_US |
| dc.subject | C reactive protein | en_US |
| dc.subject | Cupressus Sempervirens extract | en_US |
| dc.subject | ginseng extract | en_US |
| dc.subject | interleukin 6 | en_US |
| dc.subject | malonaldehyde | en_US |
| dc.subject | Nigella sativa extract | en_US |
| dc.subject | plant extract | en_US |
| dc.subject | silymarin | en_US |
| dc.subject | superoxide dismutase | en_US |
| dc.subject | unclassified drug | en_US |
| dc.subject | animal experiment | en_US |
| dc.subject | animal model | en_US |
| dc.subject | animal tissue | en_US |
| dc.subject | antioxidant activity | en_US |
| dc.subject | Article | en_US |
| dc.subject | black cumin | en_US |
| dc.subject | blood sampling | en_US |
| dc.subject | cell transformation | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | Cupressus | en_US |
| dc.subject | cytokine production | en_US |
| dc.subject | DNA binding assay | en_US |
| dc.subject | enzyme linked immunosorbent assay | en_US |
| dc.subject | experimental hepatocellular carcinoma | en_US |
| dc.subject | ginseng | en_US |
| dc.subject | herbal medicine | en_US |
| dc.subject | histopathology | en_US |
| dc.subject | immunohistochemistry | en_US |
| dc.subject | liver function | en_US |
| dc.subject | liver protection | en_US |
| dc.subject | liver tissue | en_US |
| dc.subject | male | en_US |
| dc.subject | nonhuman | en_US |
| dc.subject | oxidative stress | en_US |
| dc.subject | priority journal | en_US |
| dc.subject | rat | en_US |
| dc.title | IL-6 and NFE2L2: A putative role for the hepatoprotective effect of N. Sativa, P. Ginseng and C. Sempervirens in AFB-1 induced hepatocellular carcinoma in rats | en_US |
| dc.type | Article | en_US |
| dcterms.isReferencedBy | Ahmed Mohammed, H.A., Factors Influencing Surveillance for Hepatocellular Carcinoma in Patients with Liver Cirrhosis (2017) Liver Cancer, 6 (2), pp. 126-136; Siegel, R.L., Miller, K.D., Jemal, A., Cancer statistics, 2016 (2016) CA Cancer J Clin, 66 (1), pp. 7-30; Liu, Z., Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation (2017) Oncol Rep, 37 (2), pp. 754-760; Anwar, W.A., Changing pattern of hepatocellular carcinoma (HCC) and its risk factors in Egypt: possibilities for prevention (2008) Mutat Res, 659 (1-2), pp. 176-184; Abdel-Hamid, N.M., Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma? (2013) Environ Health Prev Med, 18 (1), pp. 49-56; Abdel-Aziz, F., Hepatitis C virus (HCV) infection in a community in the Nile Delta: population description and HCV prevalence (2000) Hepatology, 32 (1), pp. 111-115; Barakat, E.M., El Wakeel, L.M., Hagag, R.S., Effects of Nigella sativa on outcome of hepatitis C in Egypt (2013) World J Gastroenterol, 19 (16), pp. 2529-2536; Sun, B., Effect of the herbal formulation Jianpijiedu on the TCRVbetaCDR3 repertoire in rats with hepatocellular carcinoma and subjected to food restriction combined with laxative (2016) Exp Ther Med, 11 (3), pp. 818-826; Costa, C., Current evidence on the effect of dietary polyphenols intake on chronic diseases (2017) Food Chem Toxicol, 110, pp. 286-299; Dajani, E.Z., Shahwan, T.G., Dajani, N.E., Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance (2016) J Physiol Pharmacol, 67 (6), pp. 801-817; Salem, M.L., Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. (2005) Int Immunopharmacol, 5 (13-14), pp. 1749-1770; Ragheb, A., The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review (2009) Saudi J Kidney Dis Transpl, 20 (5), pp. 741-752; Attoub, S., Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo (2013) Fundam Clin Pharmacol, 27 (5), pp. 557-569; Jafri, S.H., Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo (2010) J Exp Clin Cancer Res, 29, p. 87; Brown, R.K., The effects of thymoquinone and Doxorubicin on leukemia and cardiomyocyte cell lines (2014) Biomed Sci Instrum, 50, pp. 391-396; Elsherbiny, N.M., El-Sherbiny, M., Thymoquinone attenuates Doxorubicin-induced nephrotoxicity in rats: Role of Nrf2 and NOX4 (2014) Chem Biol Interact, 223, pp. 102-108; Al-Seeni, M.N., Nigella sativa oil protects against tartrazine toxicity in male rats (2018) Toxicol Rep, 5, pp. 146-155; Wang, C.Z., Red ginseng and cancer treatment (2016) Chin J Nat Med, 14 (1), pp. 7-16; Kim, H.S., Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial (2017) Nutrients, 9 (7); Zhou, B., Wang, J., Yan, Z., Ginsenoside Rg3 attenuates hepatoma VEGF overexpression after hepatic artery embolization in an orthotopic transplantation hepatocellular carcinoma rat model (2014) Onco Targets Ther, 7, pp. 1945-1954; Igami, K., Hepatoprotective effect of fermented ginseng and its major constituent compound K in a rat model of paracetamol (acetaminophen)-induced liver injury (2015) J Pharm Pharmacol, 67 (4), pp. 565-572; Razgonova, M.P., Panax ginseng components and the pathogenesis of Alzheimer's disease (Review) (2019) Mol Med Rep, 19 (4), pp. 2975-2998; Razgonova, M.P., Supercritical green technologies for obtaining ginsenosides from far-eastern wild ginseng panax ginseng meyer using sfe for applying in drug, food and cosmetic industries (2019) Farmacia, 67 (1), pp. 81-91; Bhattacharyya, S.S., Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz [a] anthracene-induced skin papilloma in mice: the possible role of several key signal proteins (2010) Zhong Xi Yi Jie He Xue Bao, 8 (7), pp. 645-654; Bhattacharyya, S.S., In vitro studies demonstrate anticancer activity of an alkaloid of the plant Gelsemium sempervirens (2008) Exp Biol Med (Maywood), 233 (12), pp. 1591-1601; Koriem, K.M., Gad, I.B., Nasiry, Z.K., Protective effect of Cupressus sempervirens extract against indomethacin-induced gastric ulcer in rats (2015) Interdiscip Toxicol, 8 (1), pp. 25-34; Das, R.K., Hossain, S.K., Bhattacharya, S., Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation (2005) Cancer Lett, 230 (1), pp. 90-101; Takaki, A., Yamamoto, K., Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful? (2015) World J Hepatol, 7 (7), pp. 968-979; Liu, H.T., Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial (2016) Nutr J, 15 (1), p. 85; Maurya, B.K., Trigun, S.K., Fisetin Modulates Antioxidant Enzymes and Inflammatory Factors to Inhibit Aflatoxin-B1 Induced Hepatocellular Carcinoma in Rats (2016) Oxid Med Cell Longev, 2016, p. 1972793; Ji, T., Distinct role of interleukin-6 and tumor necrosis factor receptor-1 in oval cell- mediated liver regeneration and inflammation-associated hepatocarcinogenesis (2016) Oncotarget, 7 (41), pp. 66635-66646; Ding, W.Q., Differential sensitivity of cancer cells to docosahexaenoic acid-induced cytotoxicity: the potential importance of down-regulation of superoxide dismutase 1 expression (2004) Mol Cancer Ther, 3 (9), pp. 1109-1117; Menegon, S., Columbano, A., Giordano, S., The Dual Roles of NRF2 in Cancer (2016) Trends Mol Med, 22 (7), pp. 578-593; Kim, Y.S., Protective Effect of Korean Red Ginseng against Aflatoxin B1-Induced Hepatotoxicity in Rat (2011) J Ginseng Res, 35 (2), pp. 243-249; Rotimi, O.A., Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats (2017) Toxicol Rep, 4, pp. 408-414; Al-Saffar, F.J., Ganabadi, S., Fakurazi, S., Yaakub, H., Lip, M., Chondroprotective effect of Zerumbone on Monosodium Iodoacetate induced osteoarthritis in rats (2010) Journal of Applied Sciences, 10 (4), pp. 248-260. , Chondroprotective effect of Zerumbone on Monosodium Iodoacetate induced osteoarthritis in rats. Journal of Applied Sciences, 2010. 10(4): p. 248-260; Dollah, M.A., Toxicity effect of nigella sativa on the liver function of rats (2013) Adv Pharm Bull, 3 (1), pp. 97-102; Fu, P.P., Quality assurance and safety of herbal dietary supplements (2009) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 27 (2), pp. 91-119; Vogler, G.A., Suckow, M.A., Weisbroth, S., Franklin, C.L., Anesthesia and analgesia in the laboratory rat. Eds.) (2006), pp. 627-695. , Elsevier Academic Press New York, USA; Rooney, S., Ryan, M.F., Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines (2005) Anticancer Res, 25 (3B), pp. 2199-2204; Raghunandhakumar, S., Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma (2013) Toxicol Lett, 223 (1), pp. 60-72; Umar, S., Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats (2012) Chem Biol Interact, 197 (1), pp. 40-46; Umar, S., Thymoquinone inhibits TNF-alpha-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation (2015) Toxicol Appl Pharmacol, 287 (3), pp. 299-305; Zhou, M., Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis (2017) Nat Commun, 8, p. 15433; Hamaguchi, Y., Longer warm ischemia can accelerate tumor growth through the induction of HIF-1alpha and the IL-6-JAK-STAT3 signaling pathway in a rat hepatocellular carcinoma model (2016) J Hepatobiliary Pancreat Sci, 23 (12), pp. 771-779; Kheirouri, S., Hadi, V., Alizadeh, M., Immunomodulatory Effect of Nigella sativa Oil on T Lymphocytes in Patients with Rheumatoid Arthritis (2016) Immunol Invest, 45 (4), pp. 271-283; Ma, L.N., Assessment of high-sensitivity C-reactive protein tests for the diagnosis of hepatocellular carcinoma in patients with hepatitis B-associated liver cirrhosis (2017) Oncol Lett, 13 (5), pp. 3457-3464; Deng, X.Y., Cardioprotective effects of timosaponin B II from Anemarrhenae asphodeloides Bge on isoproterenol-induced myocardial infarction in rats (2015) Chem Biol Interact, 240, pp. 22-28; Ibrahim, S.S., Nassar, N.N., Diallyl sulfide protects against N-nitrosodiethylamine-induced liver tumorigenesis: role of aldose reductase (2008) World J Gastroenterol, 14 (40), pp. 6145-6153; Ungurianu, A., Spectrophotometric versus spectrofluorometric assessment in the study of the relationships between lipid peroxidation and metabolic dysregulation (2019) Chem Biol Drug Des; Guoyin, Z., Antihepatocarcinoma Effect of Portulaca oleracea L. in Mice by PI3K/Akt/mTOR and Nrf2/HO-1/NF-kappaB Pathway (2017) Evid Based Complement Alternat Med, 2017, p. 8231358; Karin, M., Dhar, D., Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2 (2016) Carcinogenesis, 37 (6), pp. 541-546; Suzuki, T., Motohashi, H., Yamamoto, M., Toward clinical application of the Keap1-Nrf2 pathway (2013) Trends Pharmacol Sci, 34 (6), pp. 340-346; Korivi, M., Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats (2012) Evid Based Complement Alternat Med, 2012, p. 932165; Smolinski, A.T., Pestka, J.J., Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew) (2003) Food Chem Toxicol, 41 (10), pp. 1381-1390; Zhang, Y., Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3beta pathway (2016) Mol Med Rep, 14 (3), pp. 2778-2784; Lu, K.H., Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats (2017) J Ginseng Res, 41 (3), pp. 316-325; Ibrahim, N.A., El-Seedi, H.R., Mohammed, M.M., Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt (2007) Nat Prod Res, 21 (10), pp. 857-866; Ali, S.A., Protective role of Juniperus phoenicea and Cupressus sempervirens against CCl(4) (2010) World J Gastrointest Pharmacol Ther, 1 (6), pp. 123-131; Sivaramakrishnan, V., Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin (2008) Chem Biol Interact, 171 (1), pp. 79-88; Moon, H.K., Yang, E.S., Park, J.W., Protection of peroxynitrite-induced DNA damage by dietary antioxidants (2006) Arch Pharm Res, 29 (3), pp. 213-217 | |
| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.1016/j.toxrep.2019.05.008 | |
| dc.identifier.doi | PubMed ID : | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
