IL-6 and NFE2L2: A putative role for the hepatoprotective effect of N. Sativa, P. Ginseng and C. Sempervirens in AFB-1 induced hepatocellular carcinoma in rats

Aborehab N.M.; Waly N.E.

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IL-6 and NFE2L2: A putative role for the hepatoprotective effect of N. Sativa, P. Ginseng and C. Sempervirens in AFB-1 induced hepatocellular carcinoma in rats

Aborehab N.M.; Waly N.E.

Full Text link: https://t.ly/W536X

Date issued: 2019

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Doi: https://doi.org/10.1016/j.toxrep.2019.05.008 PubMed ID :

Publisher: Elsevier Inc.

Series Info: Toxicology Reports
6

Type: Article

Keywords: جامعة أكتوبر للعلوم الحديثة والآداب , MSA University , University for Modern Sciences and Arts , October University for Modern Sciences and Arts , C. Sempervirens , HCC , IL-6 , N. Sativa , NFE2L2 , P. Ginseng , alanine aminotransferase , alpha fetoprotein , aspartate aminotransferase , C reactive protein , Cupressus Sempervirens extract , ginseng extract , interleukin 6 , malonaldehyde , Nigella sativa extract , plant extract , silymarin , superoxide dismutase , unclassified drug , animal experiment , animal model , animal tissue , antioxidant activity , Article , black cumin , blood sampling , cell transformation , controlled study , Cupressus , cytokine production , DNA binding assay , enzyme linked immunosorbent assay , experimental hepatocellular carcinoma , ginseng , herbal medicine , histopathology , immunohistochemistry , liver function , liver protection , liver tissue , male , nonhuman , oxidative stress , priority journal , rat

Abstract:

In this study, we investigated possible hepato-protective effects of N. Sativa, P. Ginseng, and C. Sempervirens in Aflatoxin B1 (AFB-1) induced hepatocellular carcinoma rat model. Fifty-four male albino rats were randomly assigned to experimental groups. Alcoholic extracts of aforementioned herbs were administered orally for 28 days at different doses. IL-6, hs-CRP, MDA, SOD and NFE2L2 were determined using ELISA. Histopathological changes in treated groups were examined. Herbal treatment significantly reduced IL-6, hs-CRP, and MDA (P < 0.001) whereas it significantly increased SOD (p < 0.001). C. Sempervirens 600 and N. Sativa 1000 increased NFE2L2 level compared to P. Ginseng 500 group (P value<0.01). Histopathological evaluation of treated groups showed different grades of healing of the liver. This study confirms a beneficial hepatoprotective effect for aforementioned herbal extracts orally administered in rat model of AFB1 induced HCC. This effect is putatively mediated via modulation of inflammatory cytokines as well as amelioration of oxidative stress. � 2019