Iron oxide nanoparticulate system as a cornerstone in the effective delivery of Tc-99m radionuclide: a potential molecular imaging probe for tumor diagnosis

Swidan M.M.; Khowessah O.M.; El-Motaleb M.A.; El-Bary A.A.; El-Kolaly M.T.; Sakr T.M.

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dc.contributor.author	Swidan M.M.
dc.contributor.author	Khowessah O.M.
dc.contributor.author	El-Motaleb M.A.
dc.contributor.author	El-Bary A.A.
dc.contributor.author	El-Kolaly M.T.
dc.contributor.author	Sakr T.M.
dc.contributor.other	Labeled Compounds Department
dc.contributor.other	Hot Labs Center
dc.contributor.other	Egyptian Atomic Energy Authority
dc.contributor.other	PO13759
dc.contributor.other	Cairo
dc.contributor.other	Egypt; Pharmaceutics and Industrial Pharmacy Department
dc.contributor.other	Faculty of Pharmacy
dc.contributor.other	Cairo University
dc.contributor.other	PO11562
dc.contributor.other	Cairo
dc.contributor.other	Egypt; Radioactive Isotopes and Generator Department
dc.contributor.other	Hot Labs Center
dc.contributor.other	Egyptian Atomic Energy Authority
dc.contributor.other	PO13759
dc.contributor.other	Cairo
dc.contributor.other	Egypt; Pharmaceutical Chemistry Department
dc.contributor.other	Faculty of Pharmacy
dc.contributor.other	Modern Sciences and Arts University
dc.contributor.other	6th October City
dc.contributor.other	Egypt
dc.date.accessioned	2020-01-09T20:40:37Z
dc.date.available	2020-01-09T20:40:37Z
dc.date.issued	2019
dc.identifier.issn	15608115
dc.identifier.other	https://doi.org/10.1007/s40199-019-00241-y
dc.identifier.other	PubMed ID 30706223
dc.identifier.uri	https://t.ly/py7mO
dc.description	Scopus
dc.description	MSA Google Scholar
dc.description.abstract	Background: The evolution of nanoparticles has gained prominence as platforms for developing diagnostic and/or therapeutic radiotracers. This study aims to develop a novel technique for fabricating a tumor diagnostic probe based on iron oxide nanoparticles excluding the utilization of chelating ligands. Methods: Tc-99m radionuclide was loaded into magnetic iron oxide nanoparticles platform (MIONPs) by sonication. 99mTc-encapsulated MIONPs were fully characterized concerning particles size, charge, radiochemical purity, encapsulation efficiency, in-vitro stability and cytotoxicity. These merits were biologically evaluated in normal and solid tumor bearing mice via different delivery approaches. Results: 99mTc-encapsulated MIONPs probe was synthesized with average particle size 24.08 7.9nm, hydrodynamic size 52nm, zeta potential -28mV, radiolabeling yield 96 0.83%, high in-vitro physiological stability, and appropriate cytotoxicity behavior. The in-vivo evaluation in solid tumor bearing mice revealed that the maximum tumor radioactivity accumulation (25.39 0.57, 36.40 0.59 and 72.61 0.82%ID/g) was accomplished at 60, 60 and 30min p.i. for intravenous, intravenous with physical magnet targeting and intratumoral delivery, respectively. The optimum T/NT ratios of 57.70, 65.00 and 87.48 were demonstrated at 60min post I.V., I.V. with physical magnet targeting and I.T. delivery, respectively. These chemical and biological characteristics of our prepared nano-probe demonstrate highly advanced merits over the previously reported chelator mediated radiolabeled nano-formulations which reported maximum tumor uptakes in the scope of 3.65 0.19 to 16.21 2.56%ID/g. Conclusion: Stabilized encapsulation of 99mTc radionuclide into MIONPs elucidates a novel strategy for developing an advanced nano-sized radiopharmaceutical for tumor diagnosis. [Figure not available: see fulltext.]. 2019, Springer Nature Switzerland AG.	en_US
dc.description.uri	https://www.scimagojr.com/journalsearch.php?q=20710&tip=sid&clean=0
dc.language.iso	English	en_US
dc.publisher	Springer	en_US
dc.relation.ispartofseries	DARU, Journal of Pharmaceutical Sciences
dc.relation.ispartofseries	27
dc.subject	October University for Modern Sciences and Arts
dc.subject	جامعة أكتوبر للعلوم الحديثة والآداب
dc.subject	University of Modern Sciences and Arts
dc.subject	MSA University
dc.subject	Chelator free radiolabeling	en_US
dc.subject	Encapsulation	en_US
dc.subject	Magnetic iron oxide nanoparticles	en_US
dc.subject	Tc-99m radionuclide	en_US
dc.subject	Tumor delivery	en_US
dc.subject	Tumor diagnosis	en_US
dc.subject	magnetic iron oxide nanoparticle	en_US
dc.subject	magnetic nanoparticle	en_US
dc.subject	technetium 99m	en_US
dc.subject	ultrasmall superparamagnetic iron oxide	en_US
dc.subject	unclassified drug	en_US
dc.subject	ferric ion	en_US
dc.subject	ferric oxide	en_US
dc.subject	magnetite nanoparticle	en_US
dc.subject	technetium	en_US
dc.subject	Technetium-99	en_US
dc.subject	animal experiment	en_US
dc.subject	animal model	en_US
dc.subject	animal tissue	en_US
dc.subject	Article	en_US
dc.subject	cell viability	en_US
dc.subject	chemical parameters	en_US
dc.subject	controlled study	en_US
dc.subject	drug cytotoxicity	en_US
dc.subject	drug delivery system	en_US
dc.subject	drug stability	en_US
dc.subject	encapsulation efficiency	en_US
dc.subject	human	en_US
dc.subject	human cell	en_US
dc.subject	hydrodynamic size	en_US
dc.subject	in vitro study	en_US
dc.subject	in vivo study	en_US
dc.subject	isotope labeling	en_US
dc.subject	molecular imaging	en_US
dc.subject	mouse	en_US
dc.subject	nanoencapsulation	en_US
dc.subject	nonhuman	en_US
dc.subject	particle charge	en_US
dc.subject	particle size	en_US
dc.subject	physical parameters	en_US
dc.subject	radiochemical purity	en_US
dc.subject	synthesis	en_US
dc.subject	tumor diagnosis	en_US
dc.subject	ultrasound	en_US
dc.subject	zeta potential	en_US
dc.subject	animal	en_US
dc.subject	cancer transplantation	en_US
dc.subject	cell line	en_US
dc.subject	cell survival	en_US
dc.subject	chemistry	en_US
dc.subject	diagnostic imaging	en_US
dc.subject	intravenous drug administration	en_US
dc.subject	Administration, Intravenous	en_US
dc.subject	Animals	en_US
dc.subject	Cell Line	en_US
dc.subject	Cell Survival	en_US
dc.subject	Ferric Compounds	en_US
dc.subject	Humans	en_US
dc.subject	Magnetite Nanoparticles	en_US
dc.subject	Mice	en_US
dc.subject	Neoplasm Transplantation	en_US
dc.subject	Particle Size	en_US
dc.subject	Technetium	en_US
dc.title	Iron oxide nanoparticulate system as a cornerstone in the effective delivery of Tc-99m radionuclide: a potential molecular imaging probe for tumor diagnosis	en_US
dc.type	Article	en_US
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dcterms.source	Scopus
dc.identifier.doi	https://doi.org/10.1007/s40199-019-00241-y
dc.identifier.doi	PubMed ID 30706223
dc.Affiliation	October University for modern sciences and Arts (MSA)