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| dc.contributor.author | El-Khazragy N. | |
| dc.contributor.author | Elayat W. | |
| dc.contributor.author | Matbouly S. | |
| dc.contributor.author | Seliman S. | |
| dc.contributor.author | Sami A. | |
| dc.contributor.author | Safwat G. | |
| dc.contributor.author | Diab A. | |
| dc.contributor.other | Clinical Pathology and Hematology Department | |
| dc.contributor.other | Faculty of Medicine | |
| dc.contributor.other | Ain Shams University Biomedical Research Department | |
| dc.contributor.other | P.O. Box 11381 | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt; Department of Medical Biochemistry | |
| dc.contributor.other | Faculty of Medicine | |
| dc.contributor.other | Ain Shams University | |
| dc.contributor.other | Egypt; Department of Pediatrics | |
| dc.contributor.other | Faculty of Medicine | |
| dc.contributor.other | Ain Shams University | |
| dc.contributor.other | Egypt; Faculty of Biotechnology | |
| dc.contributor.other | October University for Modern Sciences and Arts (MSA) | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:40:35Z | |
| dc.date.available | 2020-01-09T20:40:35Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 3781119 | |
| dc.identifier.other | https://doi.org/10.1016/j.gene.2019.03.055 | |
| dc.identifier.other | PubMedID30943439 | |
| dc.identifier.uri | https://t.ly/veqn7 | |
| dc.description | Scopus | |
| dc.description | MSA Google Scholar | |
| dc.description.abstract | Long non-coding RNA (LncRNA) is recently linked to various types of cancers, CCAT and PVT1 are two LncRNAs linked to t(8;21) associated Acute Myeloid Leukemia, the interplay between CCAT, PVT1 and the MYC proto-oncogene implicated in t(8;21) could present an opportunity for using LncRNA as prognostic biomarker or a target for therapy, We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive �AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML. � 2019 Elsevier B.V. | en_US |
| dc.language.iso | English | en_US |
| dc.publisher | Elsevier B.V. | en_US |
| dc.relation.ispartofseries | Gene | |
| dc.relation.ispartofseries | 707 | |
| dc.subject | October University for Modern Sciences and Arts | |
| dc.subject | جامعة أكتوبر للعلوم الحديثة والآداب | |
| dc.subject | University of Modern Sciences and Arts | |
| dc.subject | MSA University | |
| dc.subject | Acute Myeloid Leukemia (AML) | en_US |
| dc.subject | Lnc-CCAT1 | en_US |
| dc.subject | Lnc-PVT1 | en_US |
| dc.subject | Prognostic factor | en_US |
| dc.subject | t(8;21) | en_US |
| dc.subject | long non coding RNA CCAT1 | en_US |
| dc.subject | long non coding RNA PVT1 | en_US |
| dc.subject | long untranslated RNA | en_US |
| dc.subject | tumor marker | en_US |
| dc.subject | unclassified drug | en_US |
| dc.subject | CCAT1 long noncoding RNA, human | en_US |
| dc.subject | long untranslated RNA | en_US |
| dc.subject | Myc protein | en_US |
| dc.subject | MYC protein, human | en_US |
| dc.subject | PVT1 long-non-coding RNA, human | en_US |
| dc.subject | tumor marker | en_US |
| dc.subject | acute myeloid leukemia | en_US |
| dc.subject | adult | en_US |
| dc.subject | aged | en_US |
| dc.subject | Article | en_US |
| dc.subject | cancer prognosis | en_US |
| dc.subject | cancer specific survival | en_US |
| dc.subject | clinical feature | en_US |
| dc.subject | cohort analysis | en_US |
| dc.subject | comparative study | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | demography | en_US |
| dc.subject | female | en_US |
| dc.subject | gene expression | en_US |
| dc.subject | genetic association | en_US |
| dc.subject | high risk patient | en_US |
| dc.subject | human | en_US |
| dc.subject | major clinical study | en_US |
| dc.subject | male | en_US |
| dc.subject | overall survival | en_US |
| dc.subject | priority journal | en_US |
| dc.subject | risk factor | en_US |
| dc.subject | survival rate | en_US |
| dc.subject | upregulation | en_US |
| dc.subject | acute myeloid leukemia | en_US |
| dc.subject | chromosome 21 | en_US |
| dc.subject | chromosome 8 | en_US |
| dc.subject | gene expression regulation | en_US |
| dc.subject | gene translocation | en_US |
| dc.subject | genetics | en_US |
| dc.subject | middle aged | en_US |
| dc.subject | prognosis | en_US |
| dc.subject | regression analysis | en_US |
| dc.subject | survival analysis | en_US |
| dc.subject | young adult | en_US |
| dc.subject | Adult | en_US |
| dc.subject | Aged | en_US |
| dc.subject | Biomarkers, Tumor | en_US |
| dc.subject | Chromosomes, Human, Pair 21 | en_US |
| dc.subject | Chromosomes, Human, Pair 8 | en_US |
| dc.subject | Female | en_US |
| dc.subject | Gene Expression Regulation, Neoplastic | en_US |
| dc.subject | Humans | en_US |
| dc.subject | Leukemia, Myeloid, Acute | en_US |
| dc.subject | Male | en_US |
| dc.subject | Middle Aged | en_US |
| dc.subject | Prognosis | en_US |
| dc.subject | Proto-Oncogene Proteins c-myc | en_US |
| dc.subject | Regression Analysis | en_US |
| dc.subject | RNA, Long Noncoding | en_US |
| dc.subject | Survival Analysis | en_US |
| dc.subject | Translocation, Genetic | en_US |
| dc.subject | Up-Regulation | en_US |
| dc.subject | Young Adult | en_US |
| dc.title | The prognostic significance of the long non-coding RNAs “CCAT1, PVT1” in t(8;21) associated Acute Myeloid Leukemia | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.1016/j.gene.2019.03.055 | |
| dc.identifier.doi | PubMedID30943439 | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
