Dysregulation of miR-125b predicts poor response to therapy in pediatric acute lymphoblastic leukemia
El-Khazragy N.; Elshimy A.A.; Hassan S.S.; Matbouly S.; Safwat G.; Zannoun M.; Riad R.A.
Date issued:
2019
Publisher:
Wiley-Liss Inc.
Series Info:
Journal of Cellular Biochemistry
120
Type:
Article
Keywords:
October University for Modern Sciences and Arts
,
جامعة أكتوبر للعلوم الحديثة والآداب
,
University of Modern Sciences and Arts
,
MSA University
,
Bcl-2
,
childhood acute lymphoblastic leukemia (ALL)
,
miR-125b
,
prognostic factors
,
antileukemic agent
,
microRNA 125b
,
protein bcl 2
,
acute lymphoblastic leukemia
,
Article
,
cancer chemotherapy
,
cancer prognosis
,
cancer specific survival
,
child
,
childhood leukemia
,
clinical outcome
,
controlled study
,
down regulation
,
female
,
gene expression
,
human
,
major clinical study
,
male
,
predictive value
,
priority journal
,
treatment response
Abstract:
Background: Acute lymphoblastic leukemia (ALL) is the most well-known sort of leukemia in children. In spite of favorable survival rates, some patients relapse and achieve a poor outcome. Methods: We analyzed miR-125b and Bcl-2 expressions in pediatric patients with ALL and evaluated their clinical utility as molecular markers for the prediction of disease outcomes. Results: Downregulation of miR-125b and increased Bcl-2 expression levels in pediatric patients with ALL were associated with poor prognosis at diagnosis. At day 28 of induction, miR-125b was significantly increased, whereas Bcl-2 was downregulated. Loss of miR-125b during diagnosis and its elevation after therapy are strongly correlated with short leukemia-free survival and worse survival. Moreover, the combination of miR-125b with Bcl-2 markers can clearly enhance the prediction of the disease outcome. Finally, a univariate analysis highlighted the independent prognostic value of miR-125 in a pediatric patient with ALL. Conclusions: miR-125b and Bcl-2 together are potent predictors for the prognosis and, therefore, can be used as therapeutic targets in childhood ALL. � 2018 Wiley Periodicals, Inc.
Description:
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