The prognostic significance of the long non-coding RNAs “CCAT1, PVT1” in t(8;21) associated Acute Myeloid Leukemia

El-Khazragy N.; Elayat W.; Matbouly S.; Seliman S.; Sami A.; Safwat G.; Diab A.

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The prognostic significance of the long non-coding RNAs “CCAT1, PVT1” in t(8;21) associated Acute Myeloid Leukemia

El-Khazragy N.; Elayat W.; Matbouly S.; Seliman S.; Sami A.; Safwat G.; Diab A.

Full Text link: https://t.ly/veqn7

Date issued: 2019

Doi: https://doi.org/10.1016/j.gene.2019.03.055 PubMedID30943439

Publisher: Elsevier B.V.

Series Info: Gene
707

Type: Article

Keywords: October University for Modern Sciences and Arts , جامعة أكتوبر للعلوم الحديثة والآداب , University of Modern Sciences and Arts , MSA University , Acute Myeloid Leukemia (AML) , Lnc-CCAT1 , Lnc-PVT1 , Prognostic factor , t(8;21) , long non coding RNA CCAT1 , long non coding RNA PVT1 , long untranslated RNA , tumor marker , unclassified drug , CCAT1 long noncoding RNA, human , long untranslated RNA , Myc protein , MYC protein, human , PVT1 long-non-coding RNA, human , tumor marker , acute myeloid leukemia , adult , aged , Article , cancer prognosis , cancer specific survival , clinical feature , cohort analysis , comparative study , controlled study , demography , female , gene expression , genetic association , high risk patient , human , major clinical study , male , overall survival , priority journal , risk factor , survival rate , upregulation , acute myeloid leukemia , chromosome 21 , chromosome 8 , gene expression regulation , gene translocation , genetics , middle aged , prognosis , regression analysis , survival analysis , young adult , Adult , Aged , Biomarkers, Tumor , Chromosomes, Human, Pair 21 , Chromosomes, Human, Pair 8 , Female , Gene Expression Regulation, Neoplastic , Humans , Leukemia, Myeloid, Acute , Male , Middle Aged , Prognosis , Proto-Oncogene Proteins c-myc , Regression Analysis , RNA, Long Noncoding , Survival Analysis , Translocation, Genetic , Up-Regulation , Young Adult

Abstract:

Long non-coding RNA (LncRNA) is recently linked to various types of cancers, CCAT and PVT1 are two LncRNAs linked to t(8;21) associated Acute Myeloid Leukemia, the interplay between CCAT, PVT1 and the MYC proto-oncogene implicated in t(8;21) could present an opportunity for using LncRNA as prognostic biomarker or a target for therapy, We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive �AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML. � 2019 Elsevier B.V.