Browsing by Author "Youssef M. Abdelreheem, Amal"

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FORMULATION AND EVALUATION OF NOVEL BRAIN TARGETING DRUG LOADED IN LIPID-BASED NANOPARTICLES THROUGH INTRANASAL ROUTE FOR ALZHEIMER
(irjponline, 03/01/2019) Elaty Mostafa, Dalia A.; Mostafa Hashad, Amira; Youssef M. Abdelreheem, Amal
Objective: Alzheimer's disease is a slowly progressive disease that takes 7 to 10 years from onset to death. Design and development of different lipidbased drug delivery systems (Niosomes) loaded with rivastigmine tartarate is used to solve the problem of the extensive rapid metabolism of rivastigmine. Niosomes as a nanocarriers of rivastigmine will increase its bioavailability and brain targeting. Methods: Niosomes are prepared using Hand Shaking Method (Thin Film Hydration Technique). Span 60 and cholesterol are dissolved in organic mix solvent, until forming clear solution in a round bottom flask. Then, the solvent is evaporated under decreased pressure, temperature and 70 rpm in a rotary evaporator leaving solid surfactant and cholesterol as thin film formed on the wall of the flask. This layer is then rehydrated by using aqueous solution containing drug with continuous shaking which cause swelling of surfactant layer. Swelled amphiphiles eventually fold and form vesicles that could entrap the drug. The Prepared nanoparticles were characterized for pH, particle size, surface morphology, entrapment efficiency and in vitro release study. Results The average particle size was 100.7 nm with polydispersity index of 0.232. The zeta potential of the optimized formulation F2 was determined and found to be -19 mV. Surface properties of the nanoparticles were studied by Transmission electron microscopy (TEM) and nanoparticles found to have smooth surface. The Drug entrapment efficiency was found to be in between 83.5 to 86.53% indicated fairly good drug loading in the formulations indicated increased bioavailability of the drug. optimized formulation F2 showed 60 % drug release in 240 minutes indicate sustained release of drug. Conclusion: Rivastigmine could be prepared as a novel niosomes systems to enhance its bioavailability
A Novel Vesicular Lipid Carrier Systems to Enhance Acyclovir Delivery through Skin
(International Journal of Pharmaceutical Research & Allied Sciences, 2018) Abd Elaty Mostafa, Dalia; Mostafa Hashad, Amira; Youssef M. Abdelreheem, Amal
There has always been a growing need for novel drug delivery systems to deal with chemical drug entities that have poor solubility and permeability. A great deal of interest has been being focused on the utilization of lipid based drug delivery systems such as ethosomes to enhance the permeation of antiviral drugs through the skin. Ethosomes have been employed to improve the permeability of drugs through different mechanisms. Acyclovir can pass easily through the skin to reach deep dermis layer where the virus replicates thus, enhancing the overall effect of the drug. Ethosomes comprise of various types of phospholipid structures, water, and low molecular weight alcohol (ethanol or isopropyl alcohol) in high concentration that provide malleability to the vesicle membrane. Hence, ethosomes loaded of Acyclovir were prepared with a purpose of overcoming these drawbacks. Ethosomes loaded sustained release formulations of Acyclovir were prepared using the hot method technique. The proposed formulations of Acyclovir loaded ethosomes were characterized for their morphology, particle size, zeta potential and entrapment efficiency and in vitro release study. The morphology of ethosomes showed ideal particle size and appearance. The entrapment efficiency was between 94.95 % and 98.56%, and the particle size was found between 276.3 nanometers to 677.7 nanometers. The porous structure of ethosomes was confirmed by an optical microscope and a transmission electron microscope. It also showed the highest release profile with nearly 28% release after 8 hours. F1 exhibited a zeta potential score of -67.8 indicating good stability. F1 in-vitro permeation study showed a promising penetration enhancement.