Browsing by Author "Youssef A."

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    Design, synthesis and cytotoxic activity of certain novel chalcone analogous compounds
    (Elsevier Masson SAS, 2017) El-Meligie S.; Taher A.T.; Kamal A.M.; Youssef A.; Pharmaceutical Organic Chemistry Department; Faculty of Pharmacy; Cairo University; Cairo; 11561; Egypt; Pharmaceutical Organic Chemistry Department; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); Giza; Egypt; Pharmaceutical Organic Chemistry Department; Faculty of Pharmacy and Drug Manufacturing; Misr University for Science and Technology; Giza; Egypt
    A series of chalcone analogous compounds were designed and synthesized. Replacing/substituting the enone or ethylenic bridge of the parent chalcone with rigid heterocyclic moieties or substituted aromatic amines gave nineteen target compounds. Their cytotoxic activities were screened against both breast and liver cancer cells as well as breast and liver normal cells. Target compounds were also evaluated for their inhibition activity of tubulin beta polymerization. Target compound 2e, 3a, 3b, 3c, 4a-4d, 5a, 5b and 6 showed broad spectrum excellent anticancer activity against both MCF-7 and HepG2. Compound 4a showed the most TUBb inhibition activity. � 2016 Elsevier Masson SAS
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    Modelling and simulation of 3DOF parallel manipulator using artificial neural network
    (Institute of Physics Publishing, 2019) Youssef A.; Bayoumy A.M.; Rostom M.; Tolbah F.A.; T.A at Mechatronics Dept.; Faculty of Engineering; MUST; Giza; Egypt; Mechatronics Dept.; Faculty of Engineering; MSA; Giza; Egypt; Mechatronics Dept.; Faculty of Engineering; AASMT; Cairo; Egypt; Mechatronics Dept.; Faculty of Engineering; ASU; Cairo; Egypt
    Parallel Robot (PR) has shown its ability to be precise in its movement. Actuators move simultaneously to achieve the required target, on top of that its payload is much greater than what a serial robot can withstand. To determine workspace of the robot with known angles Forward kinematics has to be introduced which, bring a lot of difficulty as it requires the solution of multiple coupled nonlinear algebraic equations. Those equations bring multiple valid solutions. Those solutions could lead to different locations. As it is not going to make the pick and place for PR will be easier. This paper will discuss a numerical method that calculates the Forward Kinematics for PR. This method uses Artificial Neural Network which relay on training with a certain number of iterations. The set of data to be used in the training can be obtained from PR simulation. This method will serve to know workspace around PR as it will help it to pick the target object. � 2019 Published under licence by IOP Publishing Ltd.