Browsing by Author "Sleem, Amany"

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    Caffeoyl Derivatives and Flavonoids from Three Compositae Species
    (Medknow Publications & Media Pvt. Ltd., 2008) Soliman, Fathy; Shehata, Afaf; Khaleel, Amal; Ezzat, Shahira M; Sleem, Amany
    Four flavones; chrysoeriol (1), apigenin (3), luteolin (6), orientin (11),and three flavanones; naringenin (2),eriodictyol (4)and 3',4',5,5',7-pentahydroxy flavanone (5), five flavonols; rhamnetin (13), hyperoside (15), rhamnetin-3-O-β-D-glucoside (17), mearnsitin-3-O-β-D-glucoside (19) andisoquercitrin (20), an aurone; 3',4',5',6-tetrahydroxyaurone-4-O-glucoside (bractein] (7), six caffeoyl derivatives of quinic acid;3,4-dicaffeoylquinic acid-methyl ester (8), 3,5-dicaffeoylquinic acid-methyl ester(9), 3,5-dicaffeoylquinic acid (10), neochlorogenic acid (12), 1,4,5-tricaffeoylquinic acid (14)and1,5-dicaffeoylquinic acid (16)and caffeic acid (18) were isolated from the flowers and the remaining aerial parts of Helichrysum bracteatum (Vent.) Andrews, Gazania nivea DC. and Dimorphotheca ecklonis DC. Compounds 8 and 9 were isolated for the first time from genus Helichrysum, compounds 10 and 12 from H.bracteatum, compounds 12-17 from genus Gazania, compounds 10, 12, 18 and 20from genus Dimorphotheca and compound 19 from genus Dimorphotheca and family Compositae. The anti-inflammatory, analgesic and antipyretic effects of the flowers and the remaining aerial parts of the three studied plants as well as the major isolated compounds of the most potent extract were studied. Bractein (7) was the most potent anti-inflammatory and antipyretic, while 3,5-dicaffeoylquinic acid (10) was the most potent analgesic. The flowers of the three plants showed a significant hepatoprotective effect
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    Cytotoxicity and Suppressive Effect of Leaves of Mimusops laurifolia on Carbon Tetrachloride-induced Liver Injury in Rats and its Bioactive Constituents
    (Asian Journal of Plant Sciences, 2012) Hifnawy, Mohamed; Sokkar, Nadia; Ezzat, Shahira M; Raslan, Mai; Y Salib, Josline; Sleem, Amany
    Since the genus Mimusops is one of the important genera in the Indian traditional medicine, and is represented in Egypt with species; Mimusops laurifolia (Forssk.) Friis., thus the plant is selected for our investigation to reveal its biological activities and phytochemically analyze its bioactive fractions. The ethanolic extract of its leaves (LEE) and its different fractions: n-hexane (HF), chloroform (CF), ethyl acetate (EAF) and n-butanol (BF) were evaluated for in vivo hepatoprotective activity against CCl4 induced hepatic cell damage in rats and for in vitro cytotoxicity against human liver cancer cell line (HEPG2); consequently the bioactive constituents were defined whereby EAF evidenced statistically significant hepatoprotection. Moreover, HF and α-amyrin (major compound isolated from HF) showed promising cytotoxicity against HEPG2. Structures of isolated compounds were established on the basis of physicochemical properties and spectral analysis. The bioactive fractions were examined for the isolation of 14 compounds for the first time from Mimusops laurifolia (Forssk.) Friis. From the lipophilic fractions: Lupeol acetate, α-amyrin, chondrillasterol, oleanolic acid, chondrillasterol-3-O-β-D-galactoside, mearnsitrin, myricetin and quercetin were isolated. While, from EAF: mearnsitrin, myricitrin, myricetin-3-O-β-D-galactoside, quercetin-3-O-β-D-glucoside, rutin and myricetin-3-O-β-D-glucuronide were isolated. Leaves of Mimusops laurifolia (Forssk.) Friis can be considered as a natural medicinal plant with a potential anticancer and hepatoprotection due to its bioactive ingredients in both HF and EAF, respectively.