Browsing by Author "Sharifi-Rad M."

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Athyrium plants - Review on phytopharmacy properties
    (National Taiwan University, 2019) Salehi B.; Ezzat, Shahira M; Tsouh Fokou P.V.; Albayrak S.; Vlaisavljevic S.; Sharifi-Rad M.; Bhatt I.D.; Sharifi-Rad M.; Belwal T.; Ayatollahi S.A.; Kobarfard F.; Ata A.; Baghalpour N.; Martorell M.; Setzer W.N.; Sharifi-Rad J.; Student Research Committee; School of Medicine; Bam University of Medical Sciences; Bam; Iran; Pharmacognosy Department; Faculty of Pharmacy; Cairo University; Kasr El-Ainy Street; Cairo; 11562; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Science and Arts (MSA)12566; Egypt; Department of Biochemistry; Faculty of Science; University of Yaounde 1; Po.Box 812; Yaounde; Cameroon; Department of Biology; Science Faculty; Erciyes University; Kayseri; 38039; Turkey; Department of Chemistry; Biochemistry and Environmental Protection; Faculty of Sciences; University of Novi Sad; Trg Dositeja Obradovica 3; Novi Sad; 21000; Serbia; Department of Range and Watershed Management; Faculty of Natural Resources; University of Zabol; Zabol; Iran; G.B. Pant National Institute of Himalayan Environment and Sustainable Development; Kosi-Katarmal; Almora; 263643; India; Department of Medical Parasitology; Zabol University of Medical Sciences; Zabol; Iran; Phytochemistry Research Center; Shahid Beheshti University of Medical Sciences; Tehran; Iran; Department of Chemistry; Richardson College for the Environmental Science Complex; The University of Winnipeg; 599 Portage Avenue; Winnipeg; MB R3B 2G3; Canada; Department of Medicinal Chemistry; School of Pharmacy; Shahid Beheshti University of Medical Sciences; Tehran; 11369; Iran; Department of Nutrition and Dietetics; Faculty of Pharmacy; University of Concepcion; Concepcion; Chile; Department of Chemistry; University of Alabama in Huntsville; Huntsville; AL 35899; United States; Food Safety Research Center (salt); Semnan University of Medical Sciences; Semnan; Iran
    Athyrium plants consist of more than 230 species that are largely distributed in the Sino-Himalayan region and the Western Pacific islands. Athyrium species are being used in traditional medicine worldwide to treat various ailments such as cough, rheumatic pain, scorpion stings, sores, burns and scalds, intestinal fever, pain, specifically breast pain during child birth, to increase milk flow, as an antiparasitic, anthelmintic, and carminative. A deep look in the literature has revealed that Athyrium species have been poorly investigated for their food preservative applications and in vivo and in vitro biological and phytochemical studies. However, some Athyrium species have demonstrated antimicrobial, anti-inflammatory, antioxidant, antiproliferative and anti-HIV potential. Athyrium multidentatum (Doll.) Ching is the most investigated species and the biological activities of their extracts, such as they antioxidant properties, seem to be related to the sulfate contents of their polysaccharides. This review provides an update on the ethnopharmacology, phytochemistry and biological properties of Athyrium plants that might be useful for further research. Of course, well-designed clinical trials will be required for some species to be used as therapy. � 2018 Center for Food and Biomolecules, National Taiwan University
  • Thumbnail Image
    Item
    Looking at marine-derived bioactive molecules as upcoming anti-diabetic agents: A special emphasis on PTP1B inhibitors
    (MDPI AG, 2018) Ezzat, Shahira M; El Bishbishy M.H.; Habtemariam S.; Salehi B.; Sharifi-Rad M.; Martins N.; Sharifi-Rad J.; Pharmacognosy Department; Faculty of Pharmacy; Cairo University; Kasr El-Ainy Street; Cairo; 11562; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Science and Arts (MSA); Cairo; 12566; Egypt; Herbal Analysis Services UK; Pharmacognosy Research Laboratories; University of Greenwich; Central Avenue; Chatham-Maritime; Kent; ME4 4TB; United Kingdom; Student Research Committee; Bam University of Medical Sciences; Bam; 44340847; Iran; Department of Medical Parasitology; Zabol University of Medical Sciences; Zabol; 61663-335; Iran; Institute for Research and Innovation in Health (i3S); University of Porto; Porto; 4200-135; Portugal; Faculty of Medicine; University of Porto; Alameda Prof. Hern�ni Monteiro; Porto; 4200-319; Portugal; Zabol Medicinal Plants Research Center; Zabol University of Medical Sciences; Zabol; 61615-585; Iran; Department of Chemistry; Richardson College for the Environmental Science Complex; University of Winnipeg; 599 Portage Avenue; Winnipeg; MB R3B 2G3; Canada
    Diabetes mellitus (DM) is a chronic metabolic disease with high morbimortality rates. DM has two types: type 1, which is often associated with a total destruction of pancreatic beta cells, and non-insulin-dependent or type 2 diabetes mellitus (T2DM), more closely associated with obesity and old age. The main causes of T2DM are insulin resistance and/or inadequate insulin secretion. Protein-tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling pathways and plays an important role in T2DM, as its overexpression may induce insulin resistance. Thus, since PTP1B may be a therapeutic target for both T2DM and obesity, the search for novel and promising natural inhibitors has gained much attention. Hence, several marine organisms, including macro and microalgae, sponges, marine invertebrates, sea urchins, seaweeds, soft corals, lichens, and sea grasses, have been recently evaluated as potential drug sources. This review provides an overview of the role of PTP1B in T2DM insulin signaling and treatment, and highlights the recent findings of several compounds and extracts derived from marine organisms and their relevance as upcoming PTP1B inhibitors. In this systematic literature review, more than 60 marine-derived metabolites exhibiting PTP1B inhibitory activity are listed. Their chemical classes, structural features, relative PTP1B inhibitory potency (assessed by IC50 values), and structure�activity relationships (SARs) that could be drawn from the available data are discussed. The upcoming challenge in the field of marine research�metabolomics�is also addressed. � 2018 by the authors.