Browsing by Author "Sen, Surjit"

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Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles
(Hindawi Publishing Corporation, 2022-09) Sharifi-Rad, Javad; Herrera-Bravo, Jesús; Semwal, Prabhakar; Painuli, Sakshi; Badoni, Himani; Ezzat, Shahira M; Farid, Mai M; Merghany, Rana M; Aborehab, Nora M; Salem, Mohamed A; Sen, Surjit; Acharya, Krishnendu; Lapava, Natallia; Martorell, Miquel; Tynybekov, Bekzat; Calina, Daniela; Cho, William C
Artemisia plants are traditional and ethnopharmacologically used to treat several diseases and in addition in food, spices, and beverages. The genus is widely distributed in all continents except the Antarctica, and traditional medicine has been used as antimalarial, antioxidant, anticancer, antinociceptive, anti-inflammatory, and antiviral agents. This review is aimed at systematizing scientific data on the geographical distribution, chemical composition, and pharmacological and toxicological profiles of the Artemisia genus. Data from the literature on Artemisia plants were taken using electronic databases such as PubMed/MEDLINE, Scopus, and Web of Science. Selected papers for this updated study included data about phytochemicals, preclinical pharmacological experimental studies with molecular mechanisms included, clinical studies, and toxicological and safety data. In addition, ancient texts and books were consulted. The essential oils and phytochemicals of the Artemisia genus have reported important biological activities, among them the artemisinin, a sesquiterpene lactone, with antimalarial activity. Artemisia absinthium L. is one of the most famous Artemisia spp. due to its use in the production of the absinthe drink which is restricted in most countries because of neurotoxicity. The analyzed studies confirmed that Artemisia plants have many traditional and pharmacological applications. However, scientific data are limited to clinical and toxicological research. Therefore, further research is needed on these aspects to understand the full therapeutic potential and molecular pharmacological mechanisms of this medicinal species.
The Pharmacological Activities of Crocus sativus L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituent
(Hindawi, 14/02/2022) Butnariu, Monica; Quispe, Cristina; Herrera-Bravo, Jesús; Sharifi-Rad, Javad; Singh, Laxman; Aborehab, Nora M; Bouyahya, Abdelhakim; Venditti, Alessandro; Sen, Surjit; Acharya, Krishnendu; Bashiry, Moein; Ezzat, Shahira M; Setzer, William N; Martorell, Miquel; Mileski, Ksenija S; Bagiu, Iulia-Cristina; Docea, Anca Oana; Calina, Daniela; Cho, William C
Crocus species are mainly distributed in North Africa, Southern and Central Europe, and Western Asia, used in gardens and parks as ornamental plants, while Crocus sativus L. (saffron) is the only species that is cultivated for edible purpose. The use of saffron is very ancient; besides the use as a spice, saffron has long been known also for its medical and coloring qualities. Due to its distinctive flavor and color, it is used as a spice, which imparts food preservative activity owing to its antimicrobial and antioxidant activity. This updated review discusses the biological properties of Crocus sativus L. and its phytoconstituents, their pharmacological activities, signaling pathways, and molecular targets, therefore highlighting it as a potential herbal medicine. Clinical studies regarding its pharmacologic potential in clinical therapeutics and toxicity studies were also reviewed. For this updated review, a search was performed in the PubMed, Science, and Google Scholar databases using keywords related to Crocus sativus L. and the biological properties of its phytoconstituents. From this search, only the relevant works were selected. The phytochemistry of the most important bioactive compounds in Crocus sativus L. such as crocin, crocetin, picrocrocin, and safranal and also dozens of other compounds was studied and identified by various physicochemical methods. Isolated compounds and various extracts have proven their pharmacological efficacy at the molecular level and signaling pathways both in vitro and in vivo. In addition, toxicity studies and clinical trials were analyzed. The research results highlighted the various pharmacological potentials such as antimicrobial, antioxidant, cytotoxic, cardioprotective, neuroprotective, antidepressant, hypolipidemic, and antihyperglycemic properties and protector of retinal lesions. Due to its antioxidant and antimicrobial properties, saffron has proven effective as a natural food preservative. Starting from the traditional uses for the treatment of several diseases, the bioactive compounds of Crocus sativus L. have proven their effectiveness in modern pharmacological research. However, pharmacological studies are needed in the future to identify new mechanisms of action, pharmacokinetic studies, new pharmaceutical formulations for target transport, and possible interaction with allopathic drugs.
Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications
(Hindawi, 2022-02) Taheri, Yasaman; Quispe, KCristina; Herrera-Bravo, Jesu´s; Sharifi-Rad, Javad; Ezzat, Shahira M; Merghany, Rana M; Shaheen, Shabnum; Azmi, Lubna; Mishra, Abhay Prakash; Sener, Bilge; Kılıç, Mehtap; Sen, Surjit; Acharya, Krishnendu; Nasiri, Azadeh; Cruz-Martins, Nata´lia; Fokou, Patrick Valere Tsouh; Ydyrys, Alibek; Bassygarayev, Zhandos; Das¸an, Sevgi Durna; Alshehri, Mohammed M; Calina, Daniela; Cho, William C
Urtica dioica belongs to the Urticaceae family and is found in many countries around the world. 1is plant contains a broad range of phytochemicals, such as phenolic compounds, sterols, fatty acids, alkaloids, terpenoids, flavonoids, and lignans, that have been widely reported for their excellent pharmacological activities, including antiviral, antimicrobial, antihelmintic, anticancer, nephroprotective, hepatoprotective, cardioprotective, antiarthritis, antidiabetic, antiendometriosis, antioxidant, anti-inflammatory, and antiaging effects. In this regard, this review highlights fresh insight into the medicinal use, chemical composition, pharmacological properties, and safety profile of U. dioica to guide future works to thoroughly estimate their clinical value.