Browsing by Author "Schwartz, Laurent"

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    Corrigendum to “Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeutic approach” [Free Radical Biology and Medicine 206 (2023) 106–110]
    (Elsevier Inc., 2023-07) Schwartz, Laurent; Alonso, Manuel Aparicio; Henry, Marc; Radman, Miroslav; Attal, Romain; Bakkarf, Ashraf
    When the authors replaced Methylene Blue (MB) with MeB throughout the paper, it unintentionally changed the words imbalance to iMeBalance, thrombosis to throMeBosis, and membrane to meMEbrane throughout the paper. This also affected references 1, 48, 51 and the author's name Lombès in refernce 91. Reference 61 also had some details missing: Anıl Kuvandık, Ecenur Özcan, Simay Serin, Hülya Sungurtekin (2021) Creutzfeldt - Jakob disease After the COVID-19 Vaccination. Turk J Intensive Care DOI: 10.4274/tybd.galenos.2021.91885 The authors apologize for any inconvenience caused. Please do not hesitate to contact me if you still need further information. © 2023 Elsevier Inc.
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    From electrons to cancer : Redox shift as a driving force of tumorigenesis
    (Elsevier, 2023-11) Attal, Romain; Bakkar, Ashraf; Bouillaud, Frederic; Devin, Anne; Henry, Marc; Ponti´e, Maxime; Radman, Miroslav; Schwartz, Laurent
    Cancer cells are very diverse but mostly share a common metabolic property: they are strongly glycolytic even though oxygen is available. Herein, the metabolic abnormalities of cancer cells are interpreted as modifications of the electric currents in redox reactions. A lower current in the electron transport chain, an increase of the concentration of reduced cofactors and a partial reversal of the tricarboxylic acid cycle are physical characteristics of several forms of cancer. The existence of electric short-circuits between oxidative branches and reductive branches of the metabolic network argue in favor of an electronic approach of cancer in the nanoscopic scale. These changes of electron flows induce a pseudo-hypoxia and the Warburg effect through succinate production and divert electrons from oxygen to biosynthetic pathways. This new look at cancer may have potential therapeutic applications.
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    Pergularia tomentosa coupled with selenium nanoparticles salvaged lead acetate-induced redox imbalance, inflammation, apoptosis, and disruption of neurotransmission in rats’ brain
    (Walter de Gruyter GmbH, 2022-11) Othman, Mohamed S; Obeidat, Sofian T; Aleid, Ghada M; Abdel-Daim, Mohamed M; Habotta, Ola A; Schwartz, Laurent; Al-Bagawi, Amal H; Hussein, Manal M; Bakkar, Ashraf
    In this study, the nepuroprotective potential of either Pergularia tomentosa leaf methanolic extract (PtE) alone or in combination with selenium nanoparticles (SeNPs-PtE) was investigated against lead acetate (PbAc)- induced neurotoxicity. Experimental rats were pretreated with PtE (100 mg/kg) or SeNPs-PtE (0.5 mg/kg) and injected intraperitoneally with PbAc (20 mg/kg) for 2 weeks. Notably, SeNPs-PtE decreased brain Pb accumulation and enhanced the level of dopamine and the activity of AChE compared to the control rats. In addition, elevated neural levels of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione along with decreased lipid peroxidation levels were noticed in pretreated groups with SeNPs-PtE. Moreover, SeNPs-PtE significantly sup- pressed neural inflammation, as indicated by lower levels of interleukin-1 beta, interleukin-6, tumor necrosis factor- alpha, nuclear factor-kappa B p65, and nitric oxide in the examined brain tissue. The molecular results also unveiled significant down-regulation in iNOS gene expression in the brains of SeNPs-PtE-treated rats. In addition, SeNPs- PtE administration counteracted the neural loss by increasing B-cell lymphoma 2 (Bcl-2) and brain-derived neurotrophic factor levels as well as decreasing BCL2-associated X protein and caspase-3 levels. To sum up, our data suggest that P. tomentosa extract alone or in combination with SeNPs has great potential in reversing the neural tissue impairment induced by PbAc via its antioxidant, anti-inflammatory, and anti-apoptotic activities. This study might have therapeutic implications in preventing and treating several lead-induced neurological disorders.