Browsing by Author "Schatz J."

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    Anti-tumor and anti-leishmanial evaluations of 1,3,4-oxadiazine, pyran derivatives derived from cross-coupling reactions of ?-bromo-6H-1,3,4- oxadiazine derivatives
    (2011) Mohareb R.M.; Schatz J.; Faculty of Pharmacy; Organic Chemistry Department; October University for Modern Science and Arts University; El-Wahaat Road; October City; Egypt; Department of Chemistry; Faculty of Science; Cairo University; Giza; A.R.; Egypt; Department Chemie und Pharmazie - Organische Chemie i; Friedrich-Alexander-Universit�t Erlangen-N�rnberg; Henkestra�e 42; D-91054 Erlangen; Germany
    Cyanoacetylhydrazine reacted with the ?-bromoacetophenones 2a,b to give hydrazide-hydrazone derivatives 3a,b. The latter products were cyclized to the 1,3,4-oxadiazine derivatives 4a,b. Bromination of the latter products gave the 6-bromo-6H-1,3,4-oxadiazine derivatives 5a,b which underwent a series of cross-coupling reactions. The antitumor evaluation of the newly synthesized products against the three cancer cells namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have high inhibitory effect towards three cell lines which is higher than the standard. Moreover, the anti-leishmanial activity of the newly synthesized product was tested on Leishmania donovani amastigotes showed that some compounds have high activity. � 2011 Published by Elsevier Ltd. All rights reserved.