Browsing by Author "Sabry, Omar"

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    Acovenoside A as a novel therapeutic approach to boost taxol and carboplatin apoptotic and antiproliferative activities in NSCLC: Interplay of miR-630/miR- 181a and apoptosis genes
    (Academic Press Inc., 2023-07) Aborehab, Nora M; Abd-Elmawla, Mai A; ElSayed, Abeer M; Sabry, Omar; Ezzat, Shahira M; Abd-Elmawla, Mai A; ElSayed, Abeer M; Sabry, Omar
    The aim of the present study is to explore the potential anticancer effect of the cardenolide; 2 acovenoside A against non-small cell lung cancer, understand its molecular mechanism in inducing 3 apoptosis and show the effect of its combination with carboplatin and taxol. MTT assay showed that the 4 combination of acovenoside A with taxol and carboplatin caused 78.9% cytotoxicity reflecting the 5 synergistic effect. The triple combination showed the best growth inhibition efficiency where the 6 number of cells at the G2/M phase was decreased and boosted up apoptotic and necrotic activity. The 7 combination also showed the most remarkable increase in gene expression of Bax and p53 and the least 8 level of Bcl2. The gene expression of miRNA181a and miRNA630 was significantly upregulated in cell 9 lines treated with the combination. The present study has proven that the underlying mechanism of 10 acovenoside A is partially attributed to the upregulation of miR-630 and miR-181a gene expressions 11 which in turn targets the intrinsic apoptosis genes as p53, Bax and Bcl2 as well as caspase 3. The present 12 study is the first to address the valuable effect of using acovenoside A together with carboplatin and 13 taxol in the treatment of NSCLC via exerting apoptotic, antiproliferative, and cytotoxic ef
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    Furlow Palatoplasty and Tonsillectomy for Treating Patients With Submucous Cleft Palate and Tonsillar Hypertrophy: A One-Stage Procedure
    (Springer, 2022-07) Abdel-Aziz, Mosaad; Abdel-Fattah, Gamal; Abdel-Aziz, Nada M; Sabry, Omar; Elsherbeeny, Motaz
    re Favorites Permissions BRIEF CLINICAL STUDIES Furlow Palatoplasty and Tonsillectomy for Treating Patients With Submucous Cleft Palate and Tonsillar Hypertrophy: A One-Stage Procedure Abdel-Aziz, Mosaad MD*; Abdel-Fattah, Gamal MD†; Abdel-Aziz, Nada M. BDS‡; Sabry, Omar MD*; Elsherbeeny, Motaz MD* Author Information *Department of Otolaryngology, Kasr Alainy Faculty of Medicine, Cairo University †Department of Otolaryngology, Misr University for Science and Technology (MUST), Cairo ‡Faculty of Dentistry, October University of Modern Science and Arts, Giza, Egypt Address correspondence and reprint requests to Mosaad Abdel-Aziz, MD, 2 el-salam st., King Faisal, above el-baraka bank, Giza, Cairo, Egypt; E-mail: mosabeez@hotmail.com, mosabeez@cu.edu.eg, mosabeez@kasralainy.edu.eg The study protocol was approved by the research ethics committee of our institute. The authors report no conflicts of interest. Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website, www.jcraniofacialsurgery.com. The Journal of Craniofacial Surgery: July 26, 2022 - Volume - Issue - 10.1097/SCS.0000000000008732 doi: 10.1097/SCS.0000000000008732 BUY SDC PAP Metrics Abstract Background: Children with cleft palate are more liable to have obstructive sleep apnea than children with normal palate due to narrow airways. Tonsillar hypertrophy is a common cause of pediatric obstructive sleep apnea; hence, it is not surprising to be encountered during cleft palate repair. The aim of this study was to evaluate the feasibility of tonsillectomy and Furlow palatoplasty performed as a 1-stage operation in patients presenting with submucous cleft palate (SMCP) and tonsillar hypertrophy. Materials and Methods: Eleven pediatric patients with SMCP and hypertrophied tonsils were included in this case series study. Furlow palatoplasty and tonsillectomy were performed for the patients in 1 sitting. The evaluation of velopharyngeal function was done preoperatively and postoperatively via auditory-perceptual-assessment, nasometry, and flexible nasopharyngoscopy. In addition, the Epworth sleepiness scale for children/adolescents was administered to the parents to assess daytime sleepiness of their children. Results: The speech improved postoperatively. Auditory-perceptual-assessment showed significant reductions in hypernasal speech, nasal air escape, and weak pressure consonants. In addition, nasometry revealed significantly decreased nasalance scores for nasal and oral sentences. A postoperative increased velar movement was observed with a significant improvement in velopharyngeal closure. The preoperative Epworth sleepiness scale for children/adolescents assessment revealed excessive daytime sleepiness in 8 patients, with significant improvement of scores postoperatively. Conclusions: Removal of hypertrophied tonsils during the repair of SMCP with Furlow palatoplasty did not negatively affect speech outcome or velar movement postoperatively. It is logical to perform both procedures simultaneously in 1 sitting to avoid postoperative sleep-related breathing disorder, which may necessitate a second stage operation.