Browsing by Author "Rashed, Noha S"
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Item Development and Validation of Green Spectrophotometric Methods for Simultaneous Determination of Paracetamol, Pamabrom and Pyrilamine Maleate in Bulk and Pharmaceutical Dosage Form(SCIENCEDOMAIN INT, 2017) Mahmoud, Ebtesam S; Rashed, Noha S; Fouad, Manal M; Habib, Fawzia IFour simple and accurate spectrophotometric methods were developed for the simultaneous determination of paracetamol, pamabrom and pyrilamine maleate. The first is a zero order spectrophotometric method used for the determination of pyrilamine maleate in presence of paracetamol and pamabrom in the range of 0.5-60 mu g/mL by measuring the absorbance at 306.8 nm where paracetamol and pamabrom exhibits zero reading. The other three methods; bivariate, dual wavelength and area under the curve methods were developed for the simultaneous determination of paracetamol, pamabrom in presence of pyrilamine maleate. Bivariate calibration algorithm involves the use of two selected wavelengths; 260 nm and 280 nm for the determination of the two studied drugs. For the dual wavelength, paracetamol shows equal absorbance at 212.87 and 220.0 nm, where the differences in absorbance were measured for the determination of PBM. Similarly, differences in absorbance at 264.23 nm and 292.28 nm were measured for determination of paracetamol. In the area under curve method; the area between 237.14 to 247.14 nm was used for determination of paracetamol and 273.6 to 283.6 nm for pamabrom. Beer's law was obeyed in the concentration ranges of 1-30 mu g mL(-1) for paracetamol and pamabrom in all methods. LOD was calculated and ranges from 0.149-0.766 mu g/mL, while LOQ was found to be in the range of 0.556-1.145 mu g/mL. The proposed methods were successfully applied for the simultaneous determination of PCM, PBM and PAM in their pharmaceutical preparation without interference from additives present with mean recovery ranging from 98.99 to 101.44%. Statistical analysis of the results obtained by the proposed spectrophotometric methods compared with a reported method revealed no significant difference between the proposed and reported methods confirming accuracy and precision at 95% confidence limit. Accession Number: WOS:000428425300003Item Green Prospective Approach of Chromium Zinc Oxide Nanoparticles for Highly Ultrasensitive Electrochemical Detection of Anti-hypotensive Medication in Various Matrices(American Chemical Society, 2023-08) Otaif, Khadejah D; Fouad, Manal M; Rashed, Noha S; Hosni, Noha Y.Z; Elsonbaty, Ahmed; Elgazzar, ElsayedA highly ultrasensitive sensor that relied on Cr/ZnO-NPs was developed to detect etilefrine hydrochloride (ETF) in different matrices via a particular green voltammetric technique. The X-ray diffraction pattern showed the nanomaterials of the polycrystalline hexagonal structure. The energy-dispersive X-ray spectrum approved the presence of Cr3+ inside the host zinc oxide framework. The morphological and topological characteristics were visualized using transmission electron microscopy and atomic force microscopy micrographs describing the nanoparticles in spherical-like shape with large-surface area. The energy gap (Eg) was evaluated from transmittance (T %) and reflectance (R %) spectra within the visible region. The optimization study indicated that the Cr/ZnO-NP/CPE sensor has high sensitivity, thanks to the distinctive physical and chemical properties of the fabricated electrode. A new approach showed a great selectivity for determining ETF in different matrices in the presence of other interferents like levodopa. Under optimal circumstances, the square- wave voltammetry revealed a linear response to ETF from 0.01 to 10 μmol L−1 (r = 0.9996) with quantification and detection limits of 9.11 and 2.97 nmol L−1 , respectively. Finally, the proposed approach was effectively applied to estimate ETF in pharmaceutical dosage forms and biological fluids using simple, accurate, and selective electrochemical electrode. The greenness profile assessment of the developed method was performed using the Eco-Scale and green analytical procedure index. These tools indicated that the proposed method is an eco-friendly technique for the determination of ETF in different matrices.