Browsing by Author "Rana M. Ibrahim"

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    Clinical uses of cannabis and Catha edulis products
    (Elsevier, 2024-01-01) Shahira M. Ezzat; Passent M. Abdel Baki; Rana M. Ibrahim; Doaa Abu Elezz; Mahmoud Abdelaziz; Mohamed A. Salem
    The medicinal use of cannabis (Cannabis sativa) and khat (Catha edulis) as well as their products has been increased in the last decade. Medical cannabis and khat have been legalized in several countries. Additionally, the major cannabinoids, particularly cannabidiol and tetrahydrocannabinol, have been utilized for the development of FDA-approved pharmaceuticals. The clinical applications of cannabis and C. edulis products are complicated by legislation and regulations that are varied among countries. In this chapter, the pharmacological and the side effect profiles for the clinical uses of cannabis and C. edulis products are highlighted. Although, the clinical data for their use are continuing to evolve, the legal status needs to be authorized to keep the balance between clinical applications and limitations.
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    Extraction and isolation of cannabinoids
    (Elsevier, 2024-01-01) Mohamed A. Salem; Rana M. Ibrahim; Passent M. Abdel Baki; Sohila M. Osman; Shahira M. Ezzat
    Cannabis sativa L. is one of the most important medicinal plants that belongs to the family Cannabaceae. C. sativa is a herbaceous flowering plant that is indigenous to eastern Asia, but it is now cultivated worldwide due to the importance of its active constituents known as cannabinoids. Due to the growing interest in these compounds, various methods for their extraction and isolation were proposed. In this chapter, we will have an overview about the conventional and nonconventional methods for extraction of cannabinoids both from plant material and from biological samples for forensic purposes. Also we will review the methods for isolation of such compounds from different types of extracts as well as the modern methods for metabolomics and chemometric tools for analysis of cannabinoids.