Browsing by Author "Radman, Miroslav"

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    Corrigendum to “Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeutic approach” [Free Radical Biology and Medicine 206 (2023) 106–110]
    (Elsevier Inc., 2023-07) Schwartz, Laurent; Alonso, Manuel Aparicio; Henry, Marc; Radman, Miroslav; Attal, Romain; Bakkarf, Ashraf
    When the authors replaced Methylene Blue (MB) with MeB throughout the paper, it unintentionally changed the words imbalance to iMeBalance, thrombosis to throMeBosis, and membrane to meMEbrane throughout the paper. This also affected references 1, 48, 51 and the author's name Lombès in refernce 91. Reference 61 also had some details missing: Anıl Kuvandık, Ecenur Özcan, Simay Serin, Hülya Sungurtekin (2021) Creutzfeldt - Jakob disease After the COVID-19 Vaccination. Turk J Intensive Care DOI: 10.4274/tybd.galenos.2021.91885 The authors apologize for any inconvenience caused. Please do not hesitate to contact me if you still need further information. © 2023 Elsevier Inc.
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    From electrons to cancer : Redox shift as a driving force of tumorigenesis
    (Elsevier, 2023-11) Attal, Romain; Bakkar, Ashraf; Bouillaud, Frederic; Devin, Anne; Henry, Marc; Ponti´e, Maxime; Radman, Miroslav; Schwartz, Laurent
    Cancer cells are very diverse but mostly share a common metabolic property: they are strongly glycolytic even though oxygen is available. Herein, the metabolic abnormalities of cancer cells are interpreted as modifications of the electric currents in redox reactions. A lower current in the electron transport chain, an increase of the concentration of reduced cofactors and a partial reversal of the tricarboxylic acid cycle are physical characteristics of several forms of cancer. The existence of electric short-circuits between oxidative branches and reductive branches of the metabolic network argue in favor of an electronic approach of cancer in the nanoscopic scale. These changes of electron flows induce a pseudo-hypoxia and the Warburg effect through succinate production and divert electrons from oxygen to biosynthetic pathways. This new look at cancer may have potential therapeutic applications.