Browsing by Author "Mostafa, Dalia A."

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Reduction of intraocular pressure using timolol orally dissolving strips in the treatment of induced primary open-angle glaucoma in rabbits
(royal pharmaceutical society, 2020-03) El‐Feky, Yasmin A.; Mostafa, Dalia A.; Al-Sawahli, Majid M.; El‐Telbany, Rania Farag A.; Zakaria, Sherin; Fayez, Ahmed M.; Ahmed, Kawkab A.; Ebtesam M Alolayan; Dalia Farag A El-Telbany
Objective To enhance bioavailability of timolol (TML) and utilize alternatives for traditional eye drops for more patient compliance, this study was aiming to develop biodegradable orally dissolving strips (ODSs) of TML for treatment of primary open-angle glaucoma (POAG). Methods Novel ODSs of TML were formulated and optimized using solvent casting method according to full factorial design (31 .22 ). TML ODSs were charac- terized with respect to many parameters. In-vivo test was carried out using four groups of 24 New Zealand albino rabbits. POAG was induced by subconjunctival treatment of betamethasone. Histopathological examination and oxidative stress markers assay were carried out. Key findings The optimized formula (F9) exhibited a remarkably 15-s disinte- gration time and 96% dissolution rate after 10 min. The results revealed a potent significant inhibitory effect of the optimized TML ODS to reduce IOP in induced rabbits in comparison with control rabbits and TML eye drops-treated rabbits. The formula showed also high activity against oxidative stress and absence of histopathological changes in iridocorneal angle and cornea. Conclusion The ODSs could be a promising alternative delivery system for eye drops with more compliance to enhance delivery and therapeutic activity of TML in treatment of POAG.
WAFER TECHNOLOGY AS A NOVEL DRUG DELIVERY SYSTEM
(IJLSR, 2019) Mostafa, Dalia A.
The buccal cavity is considering as a door for the digestive system. It is composed of teeth, tongue, and palate. When the food enters the buccal cavity, it is moved along the pharynx and esophagus and then go onward through the stomach, small intestine, large intestine, and anal opening. When the drug is taken by the buccal delivery system, it decreases the time needed for the drug to give its action, progresses the therapeutic action of the drug and gives a better enzymatic flora for drug absorption. It provides direct entry of drug into the systemic circulation; therefore, decrease all the drawbacks of the per-oral administration of drugs as hepatic first-pass effect, pre-systemic elimination of GIT by enzymatic degradation; between different routes of drug delivery, wafers are considered the most advantageous dosage form that taken orally and gives response at once with little side effects. The buccal region is one of the most convenient and easily approachable routes for administration of the therapeutic agents to be used locally and systemically.