Browsing by Author "Meselhy, Meselhy R"

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    Chemical and biological assessment of high value pharmaceutical raw material from Egyptian orange peel
    (National Institute of Science Communication, 2022-06) Meselhy, Meselhy R; Ezzat, Shahira M; Ali, Dalia El-Sheikh; El-Adl, Mohamed; El-Shafei, Reham A; Abd El-Aziz, Marwa M; Abdel-Sattar, Essam
    In Egypt, orange juice industries generate huge amount of waste peel that could be a source of raw materials with high value and economic return. Here, we explored a better model for waste management of citrus processing waste in Egypt by developing an ecofriendly method for preparation of value added materials. A high grade pectin (HGP) was obtained from the crude acidic water extract of the peel after passing through Diaion HP20 column. The HGP showed potent antidiabetic activity at lower dose than those reported in literature. It possessed significant effect on blood glucose (BG) level, as well as parameters relevant to liver and kidney functions in streptozotocin (STZ) induced diabetic rats. On the other hand, the essential oil (EO) prepared by cold press showed the highest yield (0.72% w/w) and it is the most applicable method of isolate orange oil on pilot scale. EO showed significant antimicrobial activity against the tested food borne pathogens. In conclusion, high value materials — HGP and EO were prepared on pilot scale from the waste orange peel. While the HGP can be included in food supplement for diabetic patients, EO can be used as a natural food preservative.
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    In silico and in vitro anti-inflammatory study of phenolic compounds isolated from Eucalyptus maculata resin
    (Nature Publishing Group, 2023-02) Ali1, Dalia E; El Gedaily, Rania A; Ezzat, Shahira M; El Sawy, Maged A; Meselhy, Meselhy R; Abdel‑Sattar, Essam
    Plant resins are rich in bioactive compounds with high medicinal values. However, the chemistry and anti-infammatory activity of the resins produced by trees of the genus Eucalyptus were scarcely investigated. The infammatory targets cyclooxygenase-1 (COX-1), COX-2, TNF-, NF-B, and NO were signifcantly inhibited by the methanolic extract of Eucalyptus maculata kino resin (EME) and its CH2Cl2 soluble fraction (MCF). Sakuranetin (C1), (E)-cinnamic acid (C2), kaempferol 7- methyl ether (C3), 7-O-methyl aromadendrin (C4), and 1,6- dicinnamoyl-O-α-D-glucopyranoside (C5) were isolated from MCF. Three compounds (C1, C2, and C4) showed potent in vitro COX-1 inhibition, while C5 inhibited COX-2, TNF-α, NF-κB, and NO signifcantly. An in-silico study revealed that C5 had the highest binding afnity to the active site in COX-2 with binding energy score (S) of -14.85 kcal/mol, better than celecoxib (COX-2 inhibitor). In conclusion, 1,6-dicinnamoyl-O-α-D-glucopyranoside (C5) could be investigated further in the search for anti-infammatory agents.