Browsing by Author "Matbouly, Safa"

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    Upregulation of leukemia-induced non-coding activator RNA (LUNAR1) 3 Predicts Poor Outcome in Pediatric T-acute Lymphoblastic Leukemia
    (Elsevier, 10/26/2021) EL-Khazragy, Nashwa; Abdel Aziz, Mahfouz A; Hesham, Manar; Matbouly, Safa; Abdallah Mostafa, Sally; Bakkar, Ashraf; Abouelnile, Mariam; Noufal, Yassmin; Mahran, Nievin Ahmed; Abdlkhalek, Marwa Ali; Abdelmaksoud, Mariam Fathy
    T-cell Acute Lymphoblastic Leukemia (T-ALL) accounts for around 10-15% of all lymphoblastic leukemia in children. Previous studies have proven that dysregulation of Leukemia-induced non-coding activator RNA-1 (LUNAR1) expression promotes T-ALL cell growth by enhancing the NOTCH1/IGF-1R signaling pathway. We aimed to investigate the prognostic value of LUNAR1 in pediatric T-ALL, in addition, to find out its association with NOTCH1 and IGF-1R. The LUNAR1, NOTCH1, and IGF-IR gene expression were measured in peripheral blood (PB) samples of l85 children with T-ALL and forty non-leukemic samples as a control group. Cox regression analysis revealed that overexpression of LUNAR1, NOTCH1, and IGF-IR was significantly correlated with poor prognosis, short overall survival, and progression-free survival. We concluded that LUNAR1 could serve as an independent prognostic biomarker for T-ALL in children.