Browsing by Author "M. ELAMIR, AZZA"

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    ANTI-NUCLEAR ANTIBODY (ANA) PATTERNS IN EGYPTIAN SYSTEMIC LUPUS ERYTHEMATOSUS
    (The Egyptian Society of Parasitology, 2019) M. ELAMIR, AZZA; A. FARID, ALYAA; A. HASSAN, HEBA; S. AMIN, ESRAA
    In fact autoantibodies are immunoglobulins against self-antigens that are known as endogen antigens. Systemic lupus erythematosus (SLE) is an occasion that the body begins a fight against its own cells and organs. There are different types of autoantibodies that have been identified in recent years. The most familiar is anti-nuclear antibodies (ANA). They are created against cell nuclei, and one of the methods used for its detection and its pattern determination is indirect immunofluorescence test (IIF). IIF was used for that purpose in our study, and concluded that ANA positivity rate was higher in female patients than the male ones, where ANA was positive in 36.1% of the male patients and 48.2% of female patients. Also, the most frequent ANA patterns in SLE patients were speckled pattern, where 21.6% & 41.3% of male and female patients, respectively, have speckled pattern of ANA.
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    SEROLOGY OF THE SYSTEMIC LUPUS ERYTHEMATOSUS IN EGYPTIAN PATIENTS
    (J. Egypt. Soc. Parasitol. (JESP), 2019) A FARID, ALYAA; A EISSA, RWAN; M NADA, AHMED; M ELAMIR, MONA; M. ELAMIR, AZZA
    Systemic lupus erythematosus (SLE) is a prototypic multisystem autoimmune disease with a vast spectrum of clinical presentations including almost all body organs and tissues. The incidence of lupus has tripled in the last 40 years, mainly due to the improved diagnosis. For more than 60 years the presence of autoantibodies in patients with SLE has been known. A great effort is being made for understanding the diagnostic, pathogenic and prognostic meaning of these autoantibodies. The study demonstrated the significance of autoantibodies test in Egyptian SLE patients. The results showed that 93.3% of patients have positive ANA test, 90% have positive anti-dsDNA. Anti-Sm antibodies were in 40% and 49.3% of patients have positive anti-nucleosome antibody test. Also, 30.6% of patients deve-loped a positive anti-histone test & 26% have positive anti-ribosomal test. Anti-phospholipids antibodies were found in 44.6% of patients. Levels of C3 & C4 (0.552±0.43 & 0.125±0.12, respectively) were lower than that of control group (1.2±0.35 & 0.42±0.54 for C3 & C4, respectively). Key words: Egypt, Systemic lupus erythematosus, Autoantibodies test