Browsing by Author "Lotfy, Bassant M. M"

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    Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats
    (PeerJ Inc, 2023-12) El-Shehry, Mona S. E. F; Amrymi, Rafa A; Atia, Tarek; Lotfy, Bassant M. M; Ahmed, Salma H. A; Qutb, Sarah A; Ali, Sara B; Mohamed, Ayman S; Mousa, Mohamed R; Damanhory, Ahmed A; Metawee, Mostafa E; Sakr, Hader I
    Background: Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes’ average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins. Aim: Studying the potential therapeutic effect of Ech on phenylhydrazine (PHZ)- induced HA in rats. Methods: Eighteen rats were divided into three groups (n = 6): the control group, the phenylhydrazine-induced HA group and the Ech group, injected intraperitoneally with PHZ and supplemented with oral Ech daily for 6 days. Results: Ech resulted in a considerable increase in RBCs, WBCs, and platelets counts, hemoglobin, reduced glutathione, catalase, and glutathione-S-transferase levels, and a significant decrease in aspartate & alanine aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, bilirubin, creatinine, urea, urate, malondialdehyde & nitric oxide levels in anemic rats. Histopathological examination of liver and kidney tissue samples showed marked improvement. Conclusion: Ech ameliorated phenylhydrazine-induced HA with a hepatorenal protective effect owing to its anti-inflammatory and antioxidant properties.