Browsing by Author "Kumar, Shashank"

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Chapter 1 Phytochemicals as Sources of Drugs
(Springer, 2019) Ezzat, Shahira M; Ifemeje, Jonathan C; Kumar, Shashank; Egbuna, Chukwuebuka; Jeevanandam, Jaison
Plants have been used as medicines since ancient times, due to the presence of numerous phytocompounds that helps them to prevent and cure several diseases and disorders. They are utilized in different formulations such as herbal tea, extracts, decoctions, infusions, tincture or powder (Balick and Cox 1997; Thomas et al. 1999; Samuelsson 2004; Ujah 2019). Initially, humans started to utilize plants as food which was later segregated as medicinal plants with definite pharmacological action (Howes 2018). In the past, the methods for the application of a medicinal herb for certain ailment were mainly based on the history of the plant which was recorded in herbals. It has been reported from cave carvings and literatures that the medicinal plants are widely used in ancient health care systems, such as Ayurveda, traditional Chinese medications and several ancient medications from ancient civilizations
Phytochemicals as Lead Compounds for New Drug Discovery
(Elsevier, 09/10/2019) Kaliyaperumal, Saravanan; Ezzat, Shahira M; Kumar, Shashank; Kaliyaperumal, Saravanan
Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain
Phytochemicals as Lead Compounds for New Drug Discovery. 1st Edition, Bioactive lead compounds and molecular targets for the treatment of heart diseases.
(Elsevier, 09/10/2019) Kaliyaperumal, Saravanan; Ezzat, Shahira M; Ifemeje, Jonathan; Kumar, Shashank; Egbuna, Chukwuebuka
Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.