Browsing by Author "Khallaf, Hagar M"

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    Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients
    (Elsevier BV, 2022-12) Farag, Azza Gaber Antar; Shoeib, Mohamed Abd AlMoneam; labeeb, Azza Zagloul; Sleem, Asmaa Shaaban; Khallaf, Hagar M; Khalifa, Amany Salah; Elshaib, Mustafa Elsayed; Elnaidany, Nada Farag; Hanout, Hayam Mohamed Aboelnasr
    Background: Vitiligo is an acquired depigmented skin disorder. It has a genetic and autoimmune background. Human beta defensin-1(HBD-1) plus its gene polymorphism were linked to some autoimmune disorders. Objective: To elucidate the possible role of HBD-1 in the pathogenesis of non-segmental vitiligo (NSV) through evaluation of HBD-1 serum levels and its single nucleotide polymorphism (SNP) in patients having NSV, in addition, to correlating the results with the extent of vitiligo in those patients. Methods: A current case-control study included 50 patients having NSV and 50 controls. The authors used Vitiligo Area Scoring Index (VASI) score to assess vitiligo severity and laboratory investigations to assess serum HBD-1 level using ELISA and defensin-beta1 (DEFB1) SNP using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).