Browsing by Author "Jamil, Lubna"

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    Association between Cluster of Differentiation 24 (CD24) Polymorphism, Talin-1 gene expression and Hepatocellular Carcinoma prevalence in Egyptian population
    (9/17/2021) Hafez, Mohamed M; Abdel-Hafez, Lina Jamil M; Jamil, Lubna; Ibrahim, Sherine M
    Background: Hepatitis C is considered one of the most popular diseases in Egypt. We aim is to clarify the association between Cluster of Differentiation 24 (CD24) polymorphism, Talin-1 gene expression, and the prevalence of hepatocellular carcinoma in Egyptian Hepatitis C virus patients. Methods: The link between CD24 polymorphism rs8734 and the prevalence of hepatocellular carcinoma was assessed between 200 control subjects and 400 hepatitis C virus patients (HCV), patients were classified as follows; 200 patients with HCV and 200 with HCV and hepatocellular carcinoma (HCC) by histopathological assessment and PCR-restriction fragment length polymorphism (PCR-RFLP). Results: The hepatitis c patients with HCC showed a significant increase in alpha - fetoprotein (AFP) and Talin-1 gene expression compared to patients with HCV as well as in healthy volunteers. Furthermore, the frequencies of CD 24 170 CT/TT genotype were significantly higher in HCV patients without complications (60%) when compared to CC genotype (40%) (OR= 6 at X2= 14.41, P = 0.0007), and in HCV with HCC patients (90%) when compared to CC genotype (10%) (OR= 36 at X2= 14.41, P = 0.0007). Conclusion: These data suggest that CD24 genetic polymorphism rs8734 and Talin-1 gene expression may be a significant determinant for the prevalence of hepatocellular carcinoma in HCV patients.
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    Association between Cluster of Differentiation 24 (CD24) Polymorphism, Talin-1 gene expression and Hepatocellular Carcinoma prevalence in Egyptian population
    (Bentus, 8/13/2021) Hafez, Mohamed M; Abdel-Hafez, Lina Jamil M; Jamil, Lubna; Ibrahim, Sherine M
    Background: Hepatitis C is considered one of the most popular diseases in Egypt. We aim is to clarify the association between Cluster of Differentiation 24 (CD24) polymorphism, Talin-1 gene expression, and the prevalence of hepatocellular carcinoma in Egyptian Hepatitis C virus patients. Methods: The link between CD24 polymorphism rs8734 and the prevalence of hepatocellular carcinoma was assessed between 200 control subjects and 400 hepatitis C virus patients (HCV), patients were classified as follows; 200 patients with HCV and 200 with HCV and hepatocellular carcinoma (HCC) by histopathological assessment and PCR-restriction fragment length polymorphism (PCR-RFLP). Results: The hepatitis c patients with HCC showed a significant increase in alpha - fetoprotein (AFP) and Talin-1 gene expression compared to patients with HCV as well as in healthy volunteers. Furthermore, the frequencies of CD 24 170 CT/TT genotype were significantly higher in HCV patients without complications (60%) when compared to CC genotype (40%) (OR= 6 at X2= 14.41, P = 0.0007), and in HCV with HCC patients (90%) when compared to CC genotype (10%) (OR= 36 at X2= 14.41, P = 0.0007). Conclusion: These data suggest that CD24 genetic polymorphism rs8734 and Talin-1 gene expression may be a significant determinant for the prevalence of hepatocellular carcinoma in HCV patients.
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    Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs: Evolutionary perspective in managing pulmonary fibrosis
    (Elsevier Masson s.r.l., 2022-07-27) El-Kashef, Dalia H; Youssef, Mahmoud E; Nasr, Mohamed; Alrouji, Mohammed; Alhajlah, Sharif; AlOmeirf, Othman; El Adle Khalaf, Noura; Abdel Ghaffar, Dalia M; Jamil, Lubna; Abdel-Nasser, Zeinab M; Ibrahim, Samar; Abdeldaiem, Mahmoud Said Ibrahim; Donia, Sally S; Mohammed, Osama A; Morsy, Nesreen Elsayed; Shata, Ahmed; Saber, Sameh
    Idiopathic pulmonary fibrosis is a fatal lung disorder in which the etiology and pathogenesis are still unobvious. Effective treatments are urgently needed considering that lung transplantation is the only treatment that could improve outcomes. This study aimed to investigate the therapeutic significance of the dual administration of pimitespib, an HSP90 inhibitor, and nifuroxazide, a STAT3 inhibitor, against bleomycin-induced pulmonary