Browsing by Author "Ibrahim I.T."

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    Molecular modeling and preclinical evaluation of radioiodinated tenoxicam for inflammatory disease diagnosis
    (Springer Netherlands, 2018) Sakr T.M.; Ibrahim I.T.; Abd-Alla W.H.; Radioactive Isotopes and Generator Department; Hot Labs Center; Atomic Energy Authority; P.O. 13759; Cairo; Egypt; Pharmaceutical Chemistry Department; Faculty of Pharmacy; October University of Modern Sciences and Arts (MSA); Giza; Egypt; Labelled Compound Department; Hot Labs Center; Atomic Energy Authority; P.O. 13759; Cairo; Egypt; Department of Pharmaceutical Chemistry; Faculty of Pharmacy; Misr University for Science & Technology; P.O. 77; 6th of October; Egypt
    Abstract: The aim of the presented study is to investigate a new promising radiopharmaceutical tracer able to visualize and differentiate inflammation versus infection in early stages. Radioiodinated tenoxicam (125I-tenoxicam) was prepared and its radiochemical yield and in vitro stability were assayed. The biodistribution studies were conducted on two different mice models: sterile inflammation and bacterial infection mice models. 125I-tenoxicam showed high T/NT accumulation in the inflammatory tissues revealing high selectivity to the inflammatory tissues in contrast to infection bearing mice. The docking study using CDOCKER protocol for tenoxicam and radioiodinated tenoxicam with COX enzymes was performed to confirm that radioiodinated tenoxicam still retaining COX enzymes selectivity. � 2018, Akad�miai Kiad�, Budapest, Hungary.