Browsing by Author "Ibrahim, Mervat S"

Now showing 1 - 3 of 3

Green wastewater treatment of repurposed COVID‑19 therapy (levofoxacin) using synthesized magnetite pectin nanoparticles, comparison with mesoporous silica nanoparticles
(BioMed Central Ltd., 2023-09) El‑Maraghy, Christine M; Saleh, Sarah S; Ibrahim, Mervat S; El‑Naem, Omnia A
Rationale Antibiotics have been detected worldwide in the aquatic environment. Moreover, certain classes of antibi‑ otics have been repurposed for the management of COVID-19, which increased their use and presence in wastewater. Their occurrence even in low concentrations leads to the development of antibiotic resistance. Methodology Magnetite pectin nanoparticles (MPNP) were fabricated and compared to an established model of mesoporous silica nanoparticles (MSNP). Our studied adsorbate is levofoxacin, a fuoroquinolone antibiotic, com‑ monly used in managing COVID-19 cases. Results The infuence of various factors afecting the adsorption process was studied, such as pH, the type and con‑ centration of the adsorbent, contact time, and drug concentration. The results illustrated that the optimum adsorp‑ tion capacity for antibiotic clearance from wastewater using MPNP was at pH 4 with a contact time of 4 h; while using MSNP, it was found to be optimum at pH 7 with a contact time of 12 h at concentrations of 10 µg/mL and 16 g/L of the drug and nanoparticles, respectively, showing adsorption percentages of 96.55% and 98.89%. Drug adsorption equilibrium data obeyed the Sips isotherm model. Discussion and conclusion HPLC assay method was developed and validated. The experimental results revealed that the MPNP was as efcient as MSNP for removing the antibacterial agent. Moreover, MPNP is eco-friendly (a natu‑ ral by-product of citrus fruit) and more economic as it could be recovered and reused. The procedure was evaluated according to the greenness assessment tools: AGREE calculator and Hexagon-CALIFICAMET, showing good green scores, ensuring the process’s eco-friendliness.
A quality by design approach for the optimization of olmesartan medoxomil-orodispersible lyophilisates: In vitro/in vivo evaluation
(2022-06) Noshi, Shereen H; Dawoud, Marwa H. S; Ibrahim, Mervat S
The current study aims to develop orodispersible lyophilisates (ODLs), containing olmesartan medoxomil (OLM), by applying a quality by design approach to ensure product robustness. A thorough risk assessment study was done, where the effects of each of the types of matrix former and superdisintegrant were assessed on the drug content, friability %, cumulative drug released within 15 minutes (Q15%), disintegration time, and wetting time. This was followed by a D-optimal design, for the optimization of the ODL. The optimization study focused on studying the effects of the solubilizer concentration (X1 ) and solubilizer type (X2 ) on the disintegration time (Y1 ) and Q15% (Y2 ). A design space was created with an optimized formula, OLM-ODL, which was prepared and tested to indicate the validity of the design. The optimized formula showed fast drug release with a short disintegration time. Further characterization tests were done on OLM-ODL, as morphological examination, which showed a highly porous nature. Infrared spectroscopy showed no incompatibility. The extent of OLM absorption from the optimized ODL compared to oral OLM suspension from a pharmacokinetic study. The ODL showed an enhancement of the relative bioavailability of the optimized formula of about 345%. Thus, ODLs were successfully developed using a quality by design approach with noticeably improved biopharmaceutical performance.
Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology
(Hindawi, 7/30/2021) Egbuna, Chukwuebuka; Parmar, Vijaykumar K.; Jeevanandam, Jaison; Ezzat, Shahira M; Patrick-Iwuanyanwu, Kingsley C; Adetunji, Charles Oluwaseun; Khan, Johra; Onyeike, Eugene N; Uche, Chukwuemelie Zedech; Akram, Muhammad; Ibrahim, Mervat S; El Mahdy, Nihal M; Awuchi, Chinaza Godswill; Saravanan, Kaliyaperumal; Tijjani, Habibu; Odoh, Uchenna Estella; Messaoudi, Mohammed; Ifemeje, Jonathan C; Olisah, Michael C; Ezeofor, Nebechi Jane; Chikwendu, Chukwudi Jude; Ibeabuchi, Chinwe Gloria
Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. )e development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. )is review presents a comprehensive update on nanoparticles’ toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. Recent studies have found that nanoparticles may cause serious health effects when exposed to the body through ingestion, inhalation, and skin contact without caution. )e extent to which toxicity is induced depends on some properties, including the nature and size of the nanoparticle, the surface area, shape, aspect ratio, surface coating, crystallinity, dissolution, and agglomeration. In all, the general mechanisms by which it causes toxicity lie on its capability to initiate the formation of reactive species, cytotoxicity, genotoxicity, and neurotoxicity, among others.