Browsing by Author "Hou, V"

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    Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer
    (WILEY, 2019-08) Huy, NT; Dibas, M; Hou, V; Low, SK; Tieu, TM; Hieu, TH; El Tanany, HHM; Abd El Hamid Hassan, HH; Kamel, MG; Abd-Elhay, FA; Elhusseiny, KM
    Background We aimed to investigate the prognostic role of examined (dissected) lymph nodes (ELNs), negative LNs (NLNs), and positive (metastatic) LNs (PLNs) counts and LN ratio (LNR = PLNs/ELNsx100) in patients with major salivary gland cancer (SGC). Methods Data were retrieved for major SGC patients diagnosed between 1988 and 2011 from Surveillance, Epidemiology, and End Results program. Results We have included 5446 patients with major SGC. Most patients had parotid gland cancer (84.61%). Patients having >18 ELNs, >4 PLNs, and >33.33% LNR were associated with a worse survival. Moreover, older age, male patients, grade IV, distant stage, unmarried patients, submandibular gland cancer, and received chemotherapy but not received surgery were significantly associated with a worse survival. Conclusions We demonstrated that patients with >18 ELNs and >4 PLNs counts, and >33.33% LNR were high-risk group patients. We strongly suggest adding the ELNs and PLNs counts and/or LNR into the current staging system.
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    Survival predictors of major salivary gland cancer
    (OXFORD UNIV PRESS, 2018-11) Elhusseiny, K.M; Abd-Elhay, F.A.; Kamel, M.G; Abd El Hamid Hassan, H.H; Muhammad El Tanany, H.H; Hong, H.T; Tieu, T.M; Low, S.K; Hou, V; Dibas, M.; Huy, N.T
    Background Salivary gland cancer (SGC) represents about 3-5% of all head and neck cancers. Sadly, a rise of its annual incidence has been reported worldwide with a range of 0.5 to 2 per 100,000. In this study, we hypothesized new prognostic models for SGC including examined lymph nodes (LNs), negative (NLNs), positive (metastatic) LNs (PLNs) counts, and LN ratio (LNR=PLNs/ELNs×100). Methods The patient data of this retrospective population-based study were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. The X-tile program was used to determine the best threshold of ELNs, NLNs, PLNs counts, and LNR depending on the appropriate threshold with the minimum P-value and maximum Chi2 test. Moreover, we used Kaplan-Meier analyses to create our survival curves. Results Data for 6,175 patients with major SGC had been analyzed. From X-tile analysis, we found that patients having >21 ELNs, compared with patients having ≤6 ELNs, >3 PLNs and >40% LNR were associated with a worse survival. We also found a mean survival time of 82.36 months with overall survival and major SGC-specific survival of 54.83/70.12%, respectively. Conclusions In the current study, we have demonstrated the prognostic value of ELNs, PLNs, NLNs, and LNR. We highly suggest adding the ELNs and PLNs counts and/or LNR into the current staging system. We also encourage conducting further studies in order to shed light on mechanisms underlying the association between the ELNs and PLNs counts, LNR and major SGC survival.