Browsing by Author "Hossam Elmasry"

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    Prognostic impact of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) in Egyptian breast cancer patients
    (SAGE Publications Inc, 2024-11-12) Fayrouz A Fouad1,2 , Mohamed A Khali3 , Inas Moaz4, Hossam Elmasry1 , Nada Gheta5, Asala Abdeen5, Mariam Tantawi5, Ganna Elkholy5, Shaimaa Rihan6, Mahmoud M Kamel3 , Ayman EL-Meghawry EL-Kenawy7, Youssef AS Abdel-Moneim8 and Abdallah M Gameel; Fayrouz A Fouad; Mohamed A Khali; Inas Moaz; Hossam Elmasry; Nada Gheta; Asala Abdeen; Mariam Tantawi; Ganna Elkholy; Shaimaa Rihan; Mahmoud M Kamel; Ayman EL-Meghawry EL-Kenawy; Youssef AS Abdel-Moneim; Abdallah M Gameel
    This study aims to investigate the diagnostic and prognostic relevance of MMP-2 and MMP-9 as biomarkers for breast cancer, as well as their association with clinicopathological factors. Breast cancer is a leading contributor to cancerrelated deaths among women worldwide. The discovery of biomarkers is crucial for early diagnosis, outcome prediction, and effective treatment. Matrix metalloproteinases (MMPs) play a significant role in various physiological and pathological activities, including development, tissue repair, inflammation, cancer spread, and metastasis. While the prognostic significance of MMP-2 and MMP-9 levels in breast cancer has been studied, the findings remain inconclusive. Participants were divided into three groups, with each group consisting of 62 individuals: Group I comprised healthy controls, Group II consisted of newly diagnosed breast cancer patients (stage I-III), and Group III included patients with metastatic breast cancer. Levels of MMP-2 and MMP-9 were evaluated in these groups using the ELISA method. An evident increase in MMP-2 and MMP-9 levels was noted when comparing the control group with both the breast cancer and metastatic groups. Furthermore, a notable correlation was identified between serum MMP-9 levels and the pathological diagnosis of breast cancer (P<0.001) as well as tumor size (P<0.01). MMP-2 and MMP-9 have emerged as promising biomarkers for breast cancer, with MMP-9 specifically associated with disease prognosis. Continued investigation into the anti-tumor mechanisms of MMPs may yield significant advancements in the development of targeted therapeutic strategies for the management of breast cancer.