Browsing by Author "Hana H.Y."

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    Synthesis of novel tryptophan derivatives of potential biological activity
    (2009) Mohareb R.M.; Louca N.A.; Elmegeed G.A.; Hana H.Y.; Departament of Organic Chemistry; Faculty of Pharmacy; October University for Modem Sciences and Arts (MSA); El-Wahaat Road; October City; Egypt; Chemistry Department; Faculty of Science; Cairo University; Giza; Egypt; Hormone Department; National Research Centre; Dokki; Giza; Egypt
    Tryptophan methyl ester 2 reacts with ethyl cyanoacetate to form acetonitrilocarbonyltryptophan methylester 3. The latter reacts with cyanomethylene reagents, hydrazines, cyanomethylenes and sulfur to form the corresponding ?-pyrido-3-indolopropanoate derivatives 6a,b, pyrazolyltryptophan methyl ester derivatives 8a,b and thiophenotryptophan methyl ester derivatives 10a,b, respectively. Also compound 3 reacts with benzaldehyde to give the condensated product 12. The reactivity of the latter product towards chemical reagents was studied to form pyridine, pyrazole and isoxazole derivatives.
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    Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity
    (2008) Mohareb R.M.; Hana H.Y.; Department of Organic Chemistry; Faculty of Pharmacy; University of Modern Sciences and Arts (MSA); October City; Giza; Egypt; Hormone Department; National Research Centre; Dokki; Giza; Egypt
    The aim of this work was to synthesize steroidal heterocycles and to elucidate the potential role of these compounds as antimicrobial agents. The synthesis of steroidal heterocycles containing the pyrazole, isoxazole, thiazole, pyrane, pyridine, pyridazine, or benzopyrane ring attached to the pregnene nucleus is reported. Progesterone (1) reacts with dimethyl formamide dimethyl acetal to form enamine 2. Heterocyclization of 2 with hydrazines, hydroxylamine, glycine, ethyl acetoacetate or cyanomethylene afforded novel steroidal heterocyclic derivatives. The in vitro antimicrobial evaluation showed that all synthesized compounds show activity against the used strains of Gram positive bacteria and fungi.